Tracing To The Source Of The Supplementing Spleen And Liver Law As Well As Analysis On Medication Regularity In Treating Primary Liver Cancer Based On Data Mining Technology

Objective:Based on the study of "Huangdi Neijing",which the connotation of the supplementing spleen and liver method to study the interest,to explore the mechanism of the treatment of the liver cancer.Based on the above data mining chief physician Chang treatment of liver cancer statistical medication law.Methods:Through the study of the "Huangdi Neijing" by the original,digging on the liver and spleen as the literature,sorting out liver and spleen Zangxiang theory,and from the qi-blood and the five elements of the relationship between the liver and spleen.And then explain the connotation of tonifying the spleen and liver method.From October1,2014 to April30,2016 were Chang Zhan-jie Doctors Studio and inpatient department of hepatopathy in patients with liver cancer,established the basic information database,and collected the statistics on the patients? prescription,medication frequency and descriptive statistical analysis using Excel software.Then cluster analysis and interaction between drugs of using SPSS21.0 software.In order to study chief physician Chang in the treatment of liver cancer and the clinical experiences of drug compatibility law,and dig deep clinical experience of the supplementing spleen and liver method of liver cancer.And to investigate benefit spleen nourishing the liver treatments for liver cancer patients 1year survival rate and quality of life.The quality of life scores by ZPS(Zubrod-ECOG-WHO)standard for evaluation.The quality of life and survival status were investigated at 3,6,9 and 12 months,and the survival rate was recorded.So as to evaluate quality of life.Results:(1)From the perspective of philology to explain the the supplementing spleen and liver law.Benefits spleen connotation include:Tonifying pi,Activating pi,Warming pi,Enlivening pi,Nourishing pi.Nourishing the liver connotation includes of Liver blood,Liver Qi,Liver Yang,Blood stasis,Nourishing liver Yin.The pathogenesis of liver cancer is generally summarized as "spleen deficiency and withered wood(mines liver),toxin and blood stasis".The deficiency of Spleen Qi and the loss of liver is the pathogenesis of liver cancer.The mechanism of tonifying spleen and liver therapy of liver cancer.Namely for tonifying spleen to transport and clearing damp turbidity,complementing the vital qi,so as to enhance the ability of resistance.That is to pass through blood of the trip,help the spleen,and regulate the liver qi.The blood running is unified.It is the birth of blood qi,and the soil is to nurture the liver,not only it is to remove blood stasis for promoting tissue regeneration but also solid bundle poisonous evil.(2)Collected chief physician Chang Zhanjie?s prescription 114 cases of conventional treatment of liver cancer commonly used traditional Chinese medicine(TCM).It comprised a total of 95 hurbs,and all hurbs were used 1355 times,including 18 classes of drugs.The frequency of first seven class of drugs,that is in turn,tonifying Qi,hemorheologic agent,heat-clearing drug,qi regulating drug,promoting diuresis medicine,blood tomic,Warming yang herbs,and so on.The cumulative frequency up to 90.04%.From the drug point of view Temperature drug use the highest frequency,about 50%,hot drugs and cool drug use frequency is low.Therefore,from the clinical analysis of drug use results,when used in clinical benefit spleen nourishing the liver and is embodied in tonifying qi of the spleen,promoting blood circulation to remove blood stasis,clcaring heat ang removing toxin,clearing away heat and toxic material,Relieving qi stagnancy in liver,warming and tonifying the spleen and kidney,et al.The commonly used frequency of 42 hurbs with high clustering analysis.Fourteen drug-pairs is obtained,that consist of Liu Jinu and Yin Chen,Chen Pi and Cang Zhu,Zhi Shi and Hou Pu,Yi Yiren and Ze Xie,Lai Fuzi and Mai Ya,Bai Zhu and Fu Ling,Gui Zhi and Chai Hu,Ze Lan and Wu Zhuyu,Chi Shao and Mu Li,Yan Husuo and Niu Xi,Shan Yao and Bie Jia,Ge Gen and Jiang Huang,Ling Zhi and Yu Jin,Huang Qi and Dang Gui.Six categories of core drug-groups were obtained,there are the spleen dampness drugs,invigorating spleen and activating blood circulation drugs,Warming yang and blood remover drugs,Nourishing blood and Yin drugs,Invigorating spleen and nourishing blood.By using association rule analysis,Twenty rules are obtained.These rules reflect the medication compatibility law of spleen-liver Chang Zhanjie chief physician in the treatment of liver cancer.(3)Investigation 114 cases of liver cancer patient?s survival and quality of life.The results showed that 1 year survival rate is not statistically significant.In the improvement of quality-life,the score of patients had statistical significance(P<0.05),combineing with the spleen liver method in the treatment group and the not.This can significantly improve the quality of life of patients with liver cancer,which from the clinical data reflects the benefits of spleen and liver treatment of liver cancer effectiveness.Cnclusion:Supplementing spleen and Liver law has rich connotation,in the treatment of advanced liver cancer has a wealth of development space.It can effectively improve the quality of life of patients with liver cancer.The Chief Physician Chang Zhanjie treatment of liver cancer through the nursed back to the spleen and maintain the liver,which mobilize the function of liver germination.Through the help of liver and spleen to develop health and eliminatting pathogenic factors.The clinical thoughts of treatment difficult diseases is worth studying,and further expand the application.