Clinical Observation Of Combination Therapy For Transient Ischemic Attack With Shenxiong Tongmai Particles And Aspirin

BackgroundTIA is newly definition by the AHA/ASA TIA In 2009:TIA is transient nerve dysfunction which is due to the brain, spinal cord, or retinal focal ischemia caused by, not with acute infarction. The data shows, about a third of the clinical untreated patients with TIA attack progress for cerebral infarction. The incidence of ischemic stroke within 7 d is as high as 10%. At present, although the curative effect of western medicine is accepted, this method still can't ease part of the patients.Therefore, it is necessary to sort out the traditional Chinese medicine for the new treatments.ObjectiveObserve the curative effect of shenxiongtongmai particles and aspirin medicine combined application. Record the cases of cerebral infarction and adverse reactions.MethodAdopt the method of randomized. Collect chengdu university of traditional Chinese medicine affiliated hospital neurology department of outpatient and inpatient ward into standard of patients with transient ischemic attack during 2013.11 and 2014.9. Using the random number table method to divide into groups. All patients of two groups are are with the corresponding treatment and oral aspirin, the experimental group are treated with shenxiongtongmai particles on the basis of aspirin.Observational indexAccording to the second session of the national encephalopathy cooperation through ?the stroke precursor diagnosis and curative effect evaluation standard?,Determine the outcome by scoring method and the curative effect.(1) clinical cure:curative index(CI)>95%;:Excellent result:CI 60? 94%;Efficacious:CI 20?59%;lnvalid:CI< 20%, and CI is negative, and even strokes.(2) Record TIA episodes when one month before treatment> one and there months after treatment.(3) Record symptom integral of traditional Chinese,blood fat and hemorrheology before and after treatment.(4) Record cerebral infarction and adverse events within 1 year.Results1. Into the group:According to the testing scheme, the group of cases 110 (two groups (55 cases), actually completed cases,102 cases of experimental group (52 cases).Compared with two groups of patients' age, gender, weight, treatment, treatment before the attack number of times a month, blood lipid and blood rheology, no significant difference (P> 0.05), are comparable.2. curative index:in the experimental group,the total effective rate was 94.2%.The one of was the control group 84.0%.The ridit analysis, experimental group curative effect is better than that of control group (P< 0.05).3. Attack frequency, symptom integral of traditional Chinese, blood lipid and hemorheology of two groups of patients before and after treatment were improved, with the exception of cholesterol, the experimental group improved significantly. The combination of two medicines have the tendency of reducing cerebral infarction's occurrence.4.The patients of two groups did not fall cerebral hemorrhage, adverse reactions have no difference.ConclusionThe combination between shenxiongtongmai particles and aspirin can improve the clinical curative effect, improving the blood lipid and hemorrheology indexes. The method has the tendency of reducing cerebral infarction's occurrence without obvious adverse reactions.