The Relation Between Osteitis And Chronic Rhinosinusitis:a Meta-analysis

[Objectives] Osteitis is a relational factor of chronic rhinosinusitis(CRS), but the associations between osteitis and the severity of CRS, the prevalence of CRS with nasal polyps, previous sinus surgery is conflicting. In this study, we conducted a reduce meta-analysis to investigated the relation between osteitis and CRS.[Methods] Databases of Pub Med, Web of Science, and Embase were thoroughly searched by 2 independent Reviewer. Rev Man(versions 5.3) was used for data synthesis. The date of the patients in CRS with and without osteitis was calculated to estimate.[Results] A total of 9 studies involving 1097 participants were included. Meta-analysis showed that the SMD(standard mean difference) for Lund-Mackay score was 1.13 units(95% confidence interval: 0.72-1.54, P<0.01) between the patients in CRS with and without osteitis. The SMD for Lund-Kennedy score was 1.00 units(95%CI: 0.54-1.46,P <0.01) between the patients in CRS with and without osteitis. The OR(Odds ratio) for the prevalence of CRS with nasal polyps between the osteitis and non-osteitis group was 3.14 units,95%CI: 1.67-5.90,P <0.01. The OR for the prevalence of osteitis between revision and prima ry surgery group was 4.43 units,95%CI: 3.05-6.43,P <0.01.[Conclusions] The results of this meta-analysis showed that osteitis was significantly related with the severity of CRS, and the prevalence of CRS with nasal polyps was related with osteitis. Meanwhile, CRS patients undergoing revision surgery had a higher statistical significant prevalence of osteitis than primary surgical patients.