The Association Between Muscle Strength Level And Three Major Cardiovascular Disease Risk Factors In Elderly

Objective: The objective of this study is 1) to determine whether a relationship exists between muscle strength level and the three major cardiovascular disease risk factors in a population of elderly Chinese individuals, to determine strength evaluation index in predicting CVD risk factors and distinguish high-risk population for cardiovascular disease; 2) To identify a threshold of muscle strength associated with three major cardiovascular disease risk factors on the baseline,exploring the predictive value of muscle strength threshold;3) Follow-up a year later, to further determine the predictive value that muscle strength threshold for three major risk factors for cardiovascular disease;4) To provide the basis for the prevention of cardiovascular disease in elderly patients.Methods: Subjects were recruited in the Hangu area of Tianjin, China(male 511, female, aged ?60 years). At baseline, all subjects were invited to participate in a series of objective examination, and complete the questionnaire. A year later, all subjects will once again accept the same examination and questionnaire. Using questionnaires to collect demographic and other characteristics of the subjects and lifestyle, and physical examination, biochemical indicators, body composition and muscle strength levels and other related indicators were also carried out. Strength levels were represented with grip strength and related indices. An individual was considered a patient when they exhibited any one of three cardiovascular disease risk factors: diabetes mellitus, hypertension or dyslipidemia.Results: 1, Baseline data comparison: The prevalence of at least one three major CVD risk factor was 62.8% for men and 73.9% for women. The AUC of grip strength weight ratio was higher than grip strength and other relevant indices(AUC was 0.723 in men; AUC was 0.684 in women). Cut points of hand-grip strength/weight ratio for predicting at least one three major CVD risk factor were 0.54 in men and 0.34 in women, respectively. The adjusted OR of at least one three major CVD risk factor for those with low muscle strength was 1.95(1.25, 3.06) in men and 1.93(1.25,2.98) in women, at least two of the risk adjusted OR was 1.74(1.06,2.95) in men and 2.05(1.38, 3.04) in women.2, The change of the level of muscle strength and cardiovascular disease risk factors one year after: One year later, the grip weight ratios were 0.47 ± 0.12 and 0.32 ± 0.10 in male and female. Compared with baseline, the prevalence rates of at least one, at least two CVD risk factors in the men and women are rising, having significant differences in women but not in men.3, The characteristics of subjects with deterioration of muscle strength and new persons with CVD risk factors one year later: the number of subjects with normal muscle strength changing to poor were a total of 147 people. Compared with normal muscle strength, the rate of at least one CVD, at least two CVD risk factors in men and women who deteriorated was higher, but the difference was not statistically significant. Only the rate of at least two CVD risk factors was statistically significant. Considering the baseline critical value of the standard in men and women, after adjustment confounding factors, Persons with poor muscle strength suffering at least one CVD risk factors was 3.29 times and 2.18 times than persons with normal muscle strength in older men and women. New persons with CVD risk factors were a total of 191, compared to non CVD risk factors, the muscle strength level of both men and women had no significant difference.Conclusions: Elderly muscle strength levels decreased significantly increase the prevalence of the three major risk factors for cardiovascular disease. The optimal strength evaluation index in prediction elderly CVD risk factors was grip weight ratio. Muscle strength threshold(male grip weight ratio of 0.54, female grip weight ratio 0.34) can to some extent predict the risk of cardiovascular disease, and may provide reference for clinically elderly quantify muscle strength training management.