| Aims: This study investigated the elderly population aged 60 and above in suzhou city,Anhui Province,and analyzed the correlation between grip strength level and risk factors affecting cognition and SCD,so as to provide a better direction for reducing the prevalence of SCD and delaying the progression of cognitive decline in the elderly population in the community.Methods: From January to March,2021,264 permanent residents in a community in Suzhou,Anhui province,aged ≥60,were selected by convenient sampling method as research subjects.According to the evaluation results of subjective Cognitive Decline Questionnaire 9（SCD-Q9）,the subjects were divided into SCD group and healthy control group.General information and sleep quality assessment of the two groups were collected respectively.Physical examination,biochemical indexes and grip strength tests were performed to collect data from the two groups and analyze the risk factors of subjective cognitive decline.Then,the relationship between grip strength and subjective cognitive decline was analyzed by Logistic regression analysis and linear regression analysis,and confounding factors such as gender,age and education level were included in the regression model by stepstep selection method.The correlation between grip strength and overall memory ability and daily activity ability in cognitive domains was detected by linear regression analysis stratified by gender.Results:（1）264 community residents were included in this study,including 137 females（51.89%）and 127 males（48.11%）;There were 153 subjects（57.95%）in the SCD group with a total score of（7.11±1.36）points on SCD-Q9 scale and 111 subjects（42.05%）in the normal control group with a total score of（2.66±1.31）points;（2）There were significant differences in grip strength,age,sex and sleep quality between SCD group and control group（P<0.05）.There were no significant differences in education level,physical exercise,smoking,drinking,course of hypertension,course of coronary heart disease,course of diabetes,height,weight,BMI,waist circumference,systolic blood pressure,diastolic blood pressure and heart rate（P>0.05）;（3）There were no significant differences in fasting blood glucose,h BA1 c,total cholesterol,low-density lipoprotein,brain-derived neurotrophic factor and homocysteine between SCD group and control group（P>0.05）;（4）Logistic regression analysis showed that there was a correlation between grip strength and SCD without adjusting confounding factors（P<0.05）,but there was still a correlation between grip strength and SCD after adjusting confounding factors（P<0.05）.Further linear regression analysis was conducted to explore the relationship between grip strength level and TOTAL SCORE of SCD-Q9（continuous variable）.There was a linear correlation between grip strength and cognitive score of SCD（P<0.05）,and there was still a linear correlation after adjusting corresponding confounding factors（P<0.05）;（5）The linear regression analysis showed that there was a linear correlation between grip strength and overall memory ability（P<0.05）.When the grip strength value was divided into gender groups,the linear correlation between male and female and overall memory ability still existed（P<0.05）;（6）There was a linear correlation between grip strength level and daily activity ability in the whole population（P<0.05）,and the linear correlation between daily activity ability and male and female still existed after gender grouping（P<0.05）.Conclusion: Low grip strength level,female,advanced age,and sleep disturbance are the main risk factors for SCD.The measurement of grip strength has the advantages of simplicity,low cost,and strong operability,which can be used as an indicator for community assessment of cognitive decline in the population.Further longitudinal studies are needed to evaluate the value of grip strength in predicting the progression of SCD. |
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