Correlation Between Activin A And Female Coronary Heart Disease

Objective: Determining whether there is a correlation between Activin A, menstruation and cardiovascular diseases(including coronary heart disease and other cardiovascular disease).Study Design: From October 2013 to December 2015, a total of 352 hospitalized patients aged 20 to 55 years were enrolled in cardiovascular internal medicine of tongji hospital, they were divided into two groups: 88 patients with coronary heart disease diagnosed by coronary angiography as the case group 2, the other 88 patients who cann't been confirmed as CHD by coronary angiography, as the case group 1. At the same period, we recruited volunteers at several communities surrounding in tongji hospital by advertising, match according to age stratification, enrolled 176 healthy women as control group(group 0). We used questionnaire to survey the general information including menstrual and maternal history, measured the baseline serum Activin Alevels, detecting risk indexs of cardiovascular disease including: total cholesterol(TC), total triglycerides(TG), high-density lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterol(LDL-C). Then using analysis of variance to determine whether there was any difference of AMH and other markers between this 3 groups(group 2, group 1 and group 0).Results: As to age, analysis of variance showed that there was no significant difference between the 3 groups. In other words, the baseline ages of 3 groups were similar, so indexs were comparable between this 3 groups. Variance analysis showed the level of Activin A were not significant between 3 groups. These indexs were significant different between 3 groups: menstrul situation(i.e., menopause or not), gravidity and systolic pressure. And variance analysis showed no difference between 3 groups as to these indexs: parity, BMI, TC, LDL-C and HDL-C. There were significant differences between group 0 and group 2 as to diastolic pressure, while no difference between group 0 and group 1, group 1 and group 2. As to TG, there were significant differences between group 0 and group 1, while no difference between group 0 and group 2, group 1 and group 2. As to blood glucose, there were significant differences between group 0 and group 1, group 0 and group 2, while no difference between group 1 and group 2.Conclusions: The level of Activin A was not closely associated with the cardiovascular disease, but menstrul situation and gravidity were associated with the cardiovascular disease. Menstrul situation and gravidity changed before the index of TC, HDL-C and LDL-C, so they may serve as predictors of cardiovascular disease risk.