The Relationship Between Coronary Microcirculation Dysfunction Assessed By IMR And Risk Factors Of Coronary Heart Disease

Objective:The coronary index of microcirculatory resistance (IMR) was measured using Doppler pressure-temperature guide wire technique so as to evaluate coronary microcirculation function Doppler pressure-temperature guide wire technique was confirmed to be a simple, effective and safe detection means The relationship between risk factors, aggregation of coronary heart disease and coronary microcirc-lation dysfunction was investigatedMethod:The coronary index of microcirculatory resistance (IMR) was detected on 97 clinical coronary heart disease patients undergoing selective coronary arteriogra-phy by Doppler pressure-temperature guide wire technology in Zhongda Hospital Affiliated to Southeast University from January 2013 to September 2014 The pressure distal (PD) microcirculation and indicator mean transit time (Tmn) were monitored by RadiAnalyzer Xpress instrument IMR value was calculated according to the simple formula IMR=pD-Tmn IMR=32U was used as the boundary value to determine whether coronary microcirculation disorder existed The fasting blood of study object was collected for routine tests and coronary heart disease related risk factors analysis (age, gender, smoking history, diabetes, hyperlipidemia and hypertension) The risk factors of all study objects were counted The effects of single risk factor and various risk factors aggregation levels on the incidence of coronary microcirculation disorder were compared. Results:1 IMR value of study object was measured by Doppler pressure-temperature guide wire technology The success rate of operation was 100% All the subjects had no relevant operation complication The operation trauma was little The operation was safe, simple and convenient The detection sensitivity was high 2 The single factor cited in this study (age, gender, smoking, hypertension, diabetes and hyperlipidemia) could be the predictive risk factor of coronary microcirculation dysfunction (P<0.05) 3 With the increase and aggregation of individual concomitant risk factor, the positive rate of coronary microcirculation dysfunction was also increased significantly (C=-2.8379,p=0.0045), which had statistical significance Conclusion:1 Coronary index of microcirculatory resistance detection was a simple, safe, quantitative and specific minimally invasive detection technique to judge coronary microcirculation dysfunction And it was the best method and diagnostic criteria to evaluate coronary microcirculation dysfunction at present 2 The positive rate of coronary microcirculation dysfunction was positively related with age, gender, smoking, hypertension, diabetes and hyperlipidemia 3 The occurrence of coronary microcirculation dysfunction was related with risk factors aggregation The more the risk factors were, the higher the incidence of coronary microcirculation dysfunction was and the more severe the degree was...