| Objective: To determine the diffrrent antibody titers of Mycoplasma pneumoniae induced children bronchial asthma, to guide early diagnosis and treatment.Methods:370 inpatient children who were diagnosised as asthma(including merge bronchopnemonia) and carried MP-Ig M antibody titer detection at the same time were recruited from January 2013 to December 2015. General characteristics, clinical signs and symptos, auxiliary examination and the treatment were retrospectively analyzed. According to their growth and immunity characteristics, we diveded them into four groups, 58 in the infant group(~1 years old), 147 in the toddler group(~3 years old), 122 in the preschool group(~6 years old), 43 in the school-age(~10 years old). According to the characteristic of seasons, we divided them into four groups, 85 in the spring group(3~4 month), 79 in the summer group(6~8 month), 122 in the autumn group(9~11 month), 84 in the winter group(12,1~2 month). According to the characteristic of diffrrent antibody titers of Mycoplasma pneumoniae, we divided them into five groups, 187 in the negative group, 43 in the 1:40 group, 55 in the 1:80 group, 37 in the 1:160 group and 48 in the 1:320 group. Calculation and statistical analyses were performed by the SPSS 16.0 software packageResults:In the disease ofasthma(including merge bronchopnemonia) which induced by MP, the detection rate(63.16%) of MP-Ig M in girls’ was higher than that(44.73%) in boys’. The MP detection rate in preschool and school-age children was the highest(60.61%) while the infants’ was the lowest(20.69%) and the low titers(including 1:40 and 1:80) was most distributed in infant and toddler. Autumn and winter was the previaled seasons(57.28%) when compared to spring and summer(39.63%). In clinical features, the incidence of dyspnea in 1:40 group(58.14%) was higher than that in 1:320 group(22.92%) and there was significant difference(P<0.05). There was no significant difference in cough, gasping, fever and gastrointestinal symptom such as vomit and diarrhea(P>0.05). The abnormality rate of CK-MB in1:40 group(46.51%) and in 1:80 group(58.82%) was higher than that in 1:320 group(25%).There was significant difference in the count of LDH(P<0.05), the index in 1:40 group(304.28±73.51U/L) was higher than that in 1:160 group(269.30±68.75U/L)and in 1:320 group(273.09±60.03U/L). The abnormality rate of both CK-MB and LDH in low titer group were higher than that in high titer group and the difference is significant. There is no significant difference in chest radiographic, sputum culture and blood culture(P>0.05). The usage rate of Azithromycin in the low titer group was lower than that in 1:160 group and 1:320 group while the usage rate of hormone was higher than that in the high titer group. There exist no significant difference in the curative effect of Azithromycin among in different antibody titers(P>0.05).Conclusions:1.Mycoplasma pneumoniae was one of the common pathogen that induced asthma in this locality. 2.The clinical characteristics of childhood induced by Mycoplasma pneumoniae: 1) The MP detection rate in girl’s was higher; 2) Most prevailed in the school-age children; 3) Occured mainly in Autumn and Winter;4) The low titers(including 1:40 and 1:80) was most distributed in infant and toddler; 5) The hormone usage rate in infant and toddler whose MP-Ig M could be detected were higher than that in elderly children and always along with the increase of myocardial enzyme(including CK-MB and LDH). |
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