Analysis Of Correlation Between Mycoplasma Pneumoniae Antibody And Cough Variant Asthma In Children

Objective: To investigate the effect of Mycoplasma pneumoniae(MP)antibody positive on lung function and allergen infection in children with cough variant asthma(CVA).Methods: 171 children with CVA were selected from the outpatient clinic of Yongchuan Hospital affiliated to Chongqing Medical University from March 2017 to March 2018.According to the positive or not of MP antibody,they were divided into CVA + MP group and CVA group.The pulmonary function and provocation test,MP antibody titer and allergen results were collected.Results: The FEV1% value of CVA+MP group was lower than that of CVA group(59.04+19.97vs81.21+18.09,P < 0.001);the proportion of moderate to severe lung function of CVA+MP group was higher than that of CVA group(24.56%vs16.37%,P< 0.001);the values of FVC,FEV1,FEV1,PEF,FEF25%,FEF50% and FEF75% of CVA+MP group were lower than those of one month after treatment(1.41+0.54vs1.85±0.63 ?0.85±0.50vs1.40±0.41?59.04±19.97vs75.11±16.83?2.46±0.81vs2.67±0.82?2.23±0.75vs2.43±0.77?1.62±0.67vs1.85±0.69?0.85±0.33vs0.99±0.32,P<0.001).The positive rates of allergens in CVA+MP group were higher than those in CVA group(60.34% vs 43.36%,P < 0.05).There was no significant difference between 1:80 of MP antibody and 1:160,1:320 of FEV1(0.87 + 0.32 vs 0.79 + 0.39 vs 0.90 + 0.57,P>0.05);there was no significant difference between CVA group and CVA + MP group(29.76%vs 14.29%,P> 0.05).Conclusion : The pulmonary function of MP-positive children was more impaired than that of MP-negative children.The main indexes of pulmonary function of MP-positive children were lower than those of MP-negative children,but the degree of pulmonary function provocation test was not significantly aggravated.Children with CVA can simultaneously detect MP antibodies and allergens.MP therapy and allergen avoidance are recommended.Pulmonary function was also impaired in children with MP antibody 1:80.Azithromycin treatment has certain significance for the recovery of pulmonary function.