| Objective:To identify the key features that are helpful for differential diagnosis of borderline ovarian tumors(BOT)and stage I and II epithelial ovarian carcinoma(EOC)by analyzing clinical data of these two diseases.Methods:We reviewed patients’ medical records from August 2012 to August 2018 and divided them into BOT group(n=60)and EOC group(n=60)according to their histopathological results.Their clinicopathological characteristics were compared and analyzed.Results:The females in BOT group were significantly younger than those in EOC group [(41.68+11.87)vs(52.08+10.21 years,P<0.05)].Preoperative gynecological ultrasound showed that there were significant differences between two groups in maximum diameter of the solid components,sound transparencies,blood flow detection rates and pelvic effusions(P< 0.05).Additionally,CT examination revealed that the density of the lesion,enhanced portion,extent of enhancement and lymphadenopathy also had dissimilarity(P< 0.05).Solid components had good predictive value for EOC(AUC=0.645),with the sensitivity of 90.0% and the specificity of 39.0%.Serum level of HE-4 and CA199 were significantly different between the two groups(P< 0.05)when associated with CA125,respectively.The predictive value for identifying tumor was higher than that of single detection(AUC were 0.692,0.722,0.687,0.686).Distribution of histopathological types showed that serous and mucinous tumors were predominant in BOT group(86.7%,52/60)and serous tumors were more common in EOC group(55%,33/60),while other pathological types were distributed evenly(P< 0.05).Conclusion:To differentiate borderline ovarian tumor from stage I and II epithelial ovarian carcinoma,we should focus more on patients age,menopausal status,size of solid components indicated by imaging examinations,blood flow signals,enhancement patterns of different portions,density of lesions,presence of lymphadenopathy,etc.In conjunction with intraoperative exploration,frozen sectionsand histopathological types,we could get a reliable conclusion in differential diagnoses and avoid inappropriate management. |
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