| Objective: This study was carried out to to explore the risk factors of gastritis cancer and the relationship between gastritis cancer and serum PGⅠ, PGⅡ, PGⅠ/Ⅱratio(PGR), G-17 and H.pylori infection. Methods: A case- control study on risk factor of gastric cancer was performed. In the study, we recruited 180 gastric cancer patients diagnosed by digestive endoscopy and pathology from Fujian Provincial Hospital and Fuzhou General Hospital of Nanjing Military Command of Chinese People’s Liberation Army, meanwhile we selected 180 control subjects without digestive apparatus disease from Physical Examination Center of Fuzhou General Hospital of Nanjing Military Command of Chinese People’s Liberation Army. All patients were 1:1 individual matching to control subjects with same gender and age within ±3 years. By using the questionnaire, the trained investigators collected data, including general information, residential environment, family history, diet, life habit at present and ten years ago and psychological factors. Data were analyzed with conditional logistic regression.The fasting blood samples were collected from gastric cancer and control groups and the serological parameters such as serum PGⅠ, PGⅡ, G-17 and H.pylori infection were measured by using ELISA, and the results were analysed with Mann-Whitney U test and Chi-square test. Results: The factors such as family history of upper gastrointestinal neoplasm(OR=4.693,95% CI:1.509~14.264), fat meat(OR=1.635,95% CI:1.054~2.592), dried and jerky(OR=2.757,95% CI:1.504~5.054), pickled vegetable(OR=2.954,95% CI:1.738~5.021)and feeling trouble in life(OR=2.548,95% CI:1.481~4.383) were found to increase the risk of gastric cancer significantly, while the factors such as fresh fruits(OR=0.393,95% CI:0.226~0.683), onion or garlic(OR=0.431,95% CI:0.255~0.730) and tea drinking(OR=0.269,95% CI:0.111~0.653) were protective factors for gastric cancer.The lever of serum PGⅡ, G-17 and H.pylori infection rate in gastric cancer patient were higher than those in control subject(P<0.05), while PGR was lower than control subject(P<0.05). The levers of serum G-17 in patients with corpus gastric cancer were higher than those in patients with antral gastric cancer(P<0.05). The levers of serum PGⅡin patients with advanced-stage of gastric cancer were higher than that in patients with early-stage of cancer(P<0.05), while PGR in patients with advanced-stage of cancer were lower than that in patients with early-stage of cancer(P<0.05). The results through analysis with conditional logistic regression revealed that the lever serum PGⅠand PGR decrease might increase the risk of gastric cancer. Conclusion: Gastric cancer may be related with many factors. Family history of neoplasm, poor dietary habits, salting food and feeling annoyed in life may be risk factors for gastric cancer, while fresh fruit, onion or garlic and tea drinking may be protective factors for gastric cancer.The levers of serum PGⅡ, G-17 and H.pylori infection rate were different between gastric cancer patients and control subjects. The elevation of G-17 may indicate the location of gastric cancer. The elevation of PGⅡand reduction of PGR may imply the clinical stage of gastric cancer. The lever of serum PGⅠand PGR decrease might be independent risk factors for gastric cancer and they may be associated with gastric cancer. |
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