The Clinical Curative Effect Observation And Experiment Study Of Qiang-zhi Powder In The Treatment Of Tourette Syndrome

Objective: To observe the Qiang-Zhi powder on Tourette(renal insufficiency Chi) before and after treatment in children with tic type, frequency, and intensity of life or behavior affect the degree of change, and with western tiapride compare efficacy, objective evaluation Chi scattered strong therapeutic effect, and through experiments, preliminary inquiry Qiang-Zhi San mechanism, intended to mark the dialectical theory of perfect restoration to provide clinical basis.Methods: 1.Clinical part: met the inclusion criteria, 60 patients were randomly divided into traditional Chinese medicine group and western medicine group, 30 cases of oral medicine group scattered Qiang-Zhi, oral medicine group tiapride. 12 weeks of treatment, followed up for 24 weeks. Before and after treatment, the total effect, motor tics, vocal tics, and the type, frequency, intensity and complexity of the twitch, the efficacy of the degree of interference of life, adverse reactions, long-term safety and efficacy. 2. Experimental part: 40 SD rats were randomly divided into control group, model group, tiapride group, Qiang-Zhi scattered groups of 10. By intraperitoneal injection IDPN, 300 mg / kg, 1 times / d, 7 consecutive d, rat model of TS. Qiang-Zhi powder group in accordance with 5 g / kg dose gavage free fried particles, sulfur Billy group in accordance with 25 mg / kg dose gavage tiapride, while the remaining two groups given equal volume of saline. Continuous gavage for 4 weeks. Locomotor activity and body weight was observed in rats and detect changes in brain DA, NE content.Results: 1.Clinical part: overall twitching, motor tics, tic frequency, tic intensity, the extent of interference of life improvement, Qiang-Zhi scattered effective than tiapride(p <0.05). In vocal tics, the type of tic aspects to improve the situation, complexity, and San Qiang-Zhi tiapride considerable effect(p> 0.05). San Qiang-Zhi TCM syndrome effect of improvement is better than tiapride(p <0.05). 2. Experimental part: Strong rat brain blogs scattered group DA, NE sulfur content than cisapride was significantly lower(p <0.05).Conclusion: Qiang-Zhi powder in treating Tourette(renal insufficiency Chi) is safe and effective, may play a therapeutic tic synthesis by reducing the role of the DA.