Evaluation Of The Clinical Effect Of Percutaneous Lumbar Discectomy Combined With Ozone For Treatment Of Lumbar Disc Herniation

OBJECTIVE The purpose of this trial was to compare the efficacy and safety of percutaneous lumbar discectomy (PLD) combined with ozone and conventional PLD for the treatment of symptomatic lumbar disc herniation (LDH).METHOD In this prospective, single-blind randomized controlled trial, we enrolled patients with symptomatic lumbar disc herniation (LDH) in our hospital. Inclusion criteria included the presence four or more weeks low back pain and/or lower-limb radiation pain as determined by provocative CT/MR test. Patients were excluded if there was greater than 50% loss of disc height or previous spinal surgery, spinal tumors, spinal stenosis, spine infections, and fractures. It is estimated that 70 patients were randomly assigned (1:1 ratio) to receive either PLD combined with ozone (experiment group) or conventional PLD (control group). The primary outcome measure include Visual Analogue Scale(VAS 0-10), Oswestry Disability Index(ODI), Japanese Orthopaedic Association(JOA) and occurrence of complications. Independent statistical analysis was performed.RESULT Between January,2015 and October 2015,70 patients were randomly assigned to received the treatment with either PLD combined with ozone(n=35) or conventional PLD(n=35). During a median follow-up of 6 month,67 patients(34 in the experiment group and 33 in the control group) were successfully completed. There was no significant difference in baseline data between two groups(P>0.05). There is a significant difference between the two groups in the VSA, ODI and JOA at post-operation 1 month,3month, 6month (P<0.05). No adverse events were reported in both two groups.CONCLUSION Percutaneous lumbar discectomy (PLD) combined with ozone appears to be safe and effective for the treatment of LDH, and is more beneficial than conventional PLD.