Wenyangyiqi Treatments For Sick Sinus Syndrome Of The Evaluation System And Analysis Of Drug Laws

Objective:Applies the method of evidence-based medicine system evaluation of wenyangyiqi method for the treatment of sick sinus syndrome clinical research literature analysis.Based on data mining,explore the characteristics of drug laws and compatibility with sick sinus syndrome,which will provide a scientific basis for chinese medicine treatment of heart failure and new ideas.Methods:1.Through the electronic retrieval and manual retrieval,retrieve wenyangyiqi method in the treatment of sick sinus syndrome of the clinical randomized controlled trials,using the Jadad score standard evaluation into the quality of research literature,using RevMan5.2 software for multiple research results the overall effect of Meta- analysis, inverted funnel chart analysis.2.based on data mining,general processing and frequency analysis of data using SPSS 17.0 software,choose the SPSS Clementine 12.0software association rules analysis,explore the medication rule.Results:1.The system evaluation were incorporated into 16 randomized controlled clinical trial, a total of 1181 patients, the Jadad score in literature quality is generally low,Meta- analysis are shown:clinical curative effect comparison of combined effect of RR(relative risk) and 95%CI: 1.41 [1.24, 1.61];dynamic electrocardiogram comparison of combined effect of RR(relative risk) and 95% CI: 2.67[2.05,3.48];the average heart ratecomparison of combined effect of MD(mean difference)and 95% CI:5.52[2.85,8.19];24h total heart rate comparison of combined effect of SMD(standardized mean difference)and 95% CI:0.87[0.50,1.24];the fastest heart rate comparison of combined effect of MD(mean difference)and 95% CI:3.95[-2.53,10.43];the slowest heart rate comparison of combined effect of MD(mean difference)and 95% CI:2.53[0.07, 5.00];SNRT comparison of combined effect of SMD( standardized mean difference) and 95% CI:-0.57[-0.86,-0.27];SACT comparison of combined effect of SMD(standardized mean difference)and 95%CI:-1.41[-2.31,-0.51].2.Data mining results:frequency of use more of the drug classes is tonic medicine, warm in medicine, relieving drugs, blood circulation drugs; sick sinus syndrome drugs mainly compatibility are as follows :Joint applications such as qi drugs and drug compatibility in temperature, the temperature inside relieving drugs and drug compatibility,as well as the temperature in medicine, tonic medicine, relieving medicine.Conclusion:Wenyangyiqi treatments for sick sinus syndrome curative effect, high safety.Mine sick sinus syndrome characteristics of the drug and compatibility,providing guidance for clinical treatment.