The Relationship Between Acute Lacunar Cerebral Infarction Cognitive Function And Uric Acid, High-sensitivity Creactive Protein

[Objective] To investigate the relationship between uric acid and high sensitive C reactive protein in patients with acute lacunar cerebral infarction and cognitive impai-rment. And understand the other risk factors of acute lacunar cerebral nfarction patients with cognitive impairment. Provide the basis for further study on the influencing factors of cognitive impairment in patients with acute lacunar cerebral infarction. To provide evidence for uric acid and high-sensitivity C reactive protein in acute lacunar cerebral infarction occurrence, development, prognosis.[Methods] 1?June 2014 to 2015 June due to 128 cases of acute lacunar cerebral infarction in the Second Affiliated Hospital of Kunming Medical University dry therapy three subjects hospitalized patients with cerebral infarction.2?To collect all the research objects of the general information and MoCA evaluation. Acute lacunar cerebral infarction patients in the hospital the next day morning fasting venous blood. Determination of uric acid (UA), high sensitive C reactive protein (hs CRP), homocysteine (Hcy), glycerin three greases (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) concentration.3?MOCA score results in patients with acute lacunar cerebral infarction were divided into two groups according to the, MOCA table Beijing version less than 25 points for cognitive dysfunction group and MOCA table is equal to or more than 25 points for normal cognitive function group.[Results] 1?Lacuna cerebral infarction after cognitive impairment group and cognitive function in normal group risk factors, sex, alcohol, Ischemic heart disease, past history of stroke or transient ischemic attack history, systolic blood pressure, diastolic blood pressure, fasting blood glucose, triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), homocysteine(Hcy), the difference was not statistically significant P>0.05. The age of cognitive dysfunction group was higher than that of non cognitive impairment group, the difference was statistically significant P<0.05. The education period of cognitive dysfunction group was lower than that of cognitive normal group, the difference was statisticallysignificant P<0.05, smoking, high blood pressure, history of diabetes was higher than the cognitive normal group, the difference was statistically significant P<0.05.Acute lacunar cerebral infarction patients with cognitive impairment group of blood uric acid (408.23 ± 58.63 umol/L) was higher than that of normal cognition group (354.20 ± 78.69 umol/L), the difference was statistically significant (P< 0.05); high sensitive C reaction protein levels (9.36 ± 7.21 mg/L) than cognitive normal group (1.24 ± 0.63 mg/L), the difference is statistically significant (P< 0.05).2? Acute lacunar cerebral infarction patients cognitive dysfunction rate was 53.13%. Acute lacunar cerebral infarction patients with cognitive impairment group MOCA score, visuospatial executive function, attention, language, abstraction, delay and memory abilities were lower than that of cognitive normal group, the difference was statistically significant (P< 0.05). 3?Multiple acute lacunar cerebral infarction patients with MOCA score lower than single acute lacunar infarction patients (P< 0.05); multiple and single acute lacunar infarction patients with UA level there is no statistical difference (P> 0.05); multiple and single acute lacunar infarction of hs CRP levels in patients with no difference (P> 0.05).4?Cortex of acute lacunar cerebral infarction patients with MOCA score lower than the cortex of acute lacunar cerebral infarction patients (P< 0.05); cortical and subcortical acute lacunar infarction patients with UA levels no significant difference (P> 0.05); cortical and subcortical acute lacunar infarction patients with hs CRP level there is no uniform difference (P> 0.05).5?Hyperuricemia patients with lacuna cerebral infarction cognitive dysfunction occurs at higher risk than non hyperuricemia patients, the difference is statistically significant P< 0.001.6?Acute lacunar cerebral infarction patients serum uric acid concentration and MOCA score was negatively correlated, and the difference is statistically significant (P= 0.032) r=-0.351; hypersensitive C reaction protein concentration and MOCA scores were negatively correlated, and thedifference is statistically significant (r=-0.269, P= 0.004).7?Years of Education (OR=0.684, P< 0.001) are the protective factors for acute lacunar cerebral infarction patients with cognitive impairment; age (OR= 1.147, P= 0.037), smoking (OR=2.931, P= 0.007), hypertension (OR=4.392, P< 0.001), diabetes mellitus (OR=3.368, P= 0.003), uric acid (OR=1.621, P< 0.001), high sensitive C reactive protein (OR=2.566, P= 0.008) were risk factors, and LI in patients with cognitive impairment.8?Years of Education (OR=0.713, P= 0.024) is an independent protective factor of acute lacunar cerebral infarction patients with cognitive dysfunction; smoking (OR=4.268, P= 0.031), hypertension (OR=26.363, P = 0.017), diabetes mellitus (OR=18.648, P= 0.025), uric acid (OR=1.759, P-0.003), high sensitivity C-reactive should (OR=2.486, P= 0.005) protein is LI in patients with cognitive impairment independent risk factors.[Conclusions] 1. In addition to the known vascular factors, uric acid, hypersensitive c-reactive protein may be affect cognitive dysfunction in patients with acute lacunar cerebral infarction of the influencing factors.2.Uric acid, hypersensitive c-reactive protein concentration change with neuropsychological scale evaluation may be improve cognitive function in diagnosis of a subsidiary of biological indicators, provide the basis for clinical.