Jinlida Particles Compare With Metformin In Treating IGR

Objective:To explore Jinlida particles in the treatment of pre diabetes(type of deficiency of both qi and Yin) in patients with clinical effect, to explore the pre diabetes(deficiency of both qi and Yin) is a safe and effective means of prevention and treatment.Method:90 pre diabetes(Qi-Yin deficiency) hospitalized patients in Yunnan Provin cial Hospital of Traditional chinese Medicine(YPHTCM) and Hospital of Kun ming were randomly divided to treatment group(45 cases), 45 patients in the control group, the treatment group was treated with oral Jinlida particles, and the control group were treated with oral administration of metformin hydroch loride tablets. The treatment lasted for 8 weeks. Observed and compared betw een the two groups of patients before and after the changes of clinical sympt oms and signs, blood glucose(FPG, PPG, Hb A1c), blood lipid(TC, TG, LD L-C and HDL-C), HOMA-IR, BMI and syndromes of traditional Chinese med icine index. The SPSS 20.0 statistical software was used for data analysis.Results:1 At the end of the treatment, the actual completion of Jinlida group 42 cases(excluding 3 cases), the metformin group actually completed 41 cases(excluding 4cases).2. After the treatment, Jinlida group and metformin group, FPG, PPG, Hb A1 c and HOMA-IR were significantly decreased(P < 0.05), after treatment, two groups of FPG, PPG, Hb A1 c and HOMA-IR were no statistical difference(P > 0.05), decrease the blood glucose and improve the insulin resistance Jinlida and metformin phase when.3. After the treatment, Jinlida group and metformin group, TC, TG, LDL-C and BMI were significantly decreased, HDL-C increased significantly(P < 0.05), after treatment, two groups of TC, TG, LDL-C, HDL-C, BMI and no statistical difference(P > 0.05), to improve blood lipids and lower BMI values Jinlida and dimethyl biguanide quite.4. The curative effect of TCM syndrome, Jinlida group the total efficiency of52.38% and metformin group total efficiency 39.02%, between the two groups is statistically significant difference(P < 0.05). TCM syndrome integral, after treatment,two groups of TCM syndrome score were significantly decreased(P < 0.05) and after treatment between the two groups of TCM syndrome integral have statistical difference(P < 0.05) and in improving the efficacy of TCM on Jinlida was superior to metformin.5. After the total curative effect, Jinlida group, the total effective rate of 45.24%,metformin group, the total efficiency of 39.02%, the total curative effect between the two groups no significant difference(Z=-1.144, P=0.252) fairly in the total clinical efficacy Jinlida and metformin.Conclusions:Jinlida particles can effectively improve the diabetes early Qi and yindeficienc-y type in patients with fasting blood glucose, postprandial two hour blood glucose,blood lipid, BMI value, glycosylated hemoglobin and TCM dyn-drome. Jinlida gran-ules of TCM symptoms improved efficacy than metformin and metformin, the total effect is similar. Jinlida particles in pre diabetes(type of deficiency of both qi and Yi-in) has a good effect of prevention and treatment, can delay or even block the predia-betes to diabetes and improve the prognosis of diabetes and pre diabetes, and pati-ents clinical compliance is better.