| Objective:To express traditional Chinese medicine syndromes distribution and drug laws of HBV-ACLF patients at The First Affiliated Hospital of Hunan University of Chinese Medicine.Method: Based on TCM clinical research information integration platform, to structured data processe and structure collection,analysis and process HBV-ACLFpatients of the first Affiliated Hospital of Hunan University of Traditional Chinese Medicine Liver Diseases(hepatitis B virus-acute liver failure),by using data mining platform and OLAP online analytical analysis, human-computer analysis of its mining syndrome distribution of TCM and drug laws.Results: 1.Syndrome Laws of HBV-ACLF:(1)syndrome distribution feature of patients with HBV-ACLF: the core present symptoms: yellow body? eyes and urine?fatigue?anorexia?abdominal distention, poor spirit, poor sleep soundly at night?nausea?bored of oil, dark urine, vomiting; core signs: yellow body, abdominal tenderness, abdominal rebound tenderness, yellow eyes, liver percussion pain positive, sickly chronic liver disease, lower extremity edema, telangiectasia, spider veins, abdominal distension.The four Chinese medical diagnostic methods distribution: Core Pulse: wiry pulse, slippery pulse, thready pulse, rapid pulse; core tongue: normal tongue, red, pink tongue, dark red tongue; core moss : greasy fur, yellow fur, white fur, thin yellow fur, thick fur.(2)the core present symptoms of Yang Huang syndrome, Yin-Yang Huang syndrome and Yin Huang syndrome are yellow body? eyes and urine?abdominal distention, nausea, bored of oil; body signs of body yellow, yellow eyes, abdominal tenderness, abdominal trans tenderness, sickly chronic liver disease, liver palms, yellow face, positive liver percussion pain, abdominal distension, spider angioma, positive shifting dullness etc; in the four Chinese medical diagnostic methods: Yang Huang syndrome, Yin-Yang Huang syndrome and Yin Huang syndrome mainly present dark face, abdominal veins, greasy fur, yellow fur, white fur, thin yellow coating, pulse string slippery pulse, thready pulse, rapid pulse, etc; four diagnostic features of Yang Huang Syndrome: yellow body and eyes like orange peel; four diagnostic features of Yin Huang Syndrome: yellow body and eyes like smoke; while yellow body and eyes like orange peel and yellow body and eyes could be present at Yin-Yang Huang syndrome. 2. Analysis of HBV-ACLFdrug laws:(1) 259 hospitalized patients had 2321 prescription medicine course records, the whole core prescription medicine: Yinchen,Chishao,Danshen,Bazhu,Yiyiren and Dahuang; the top ten overall compatibility of the highest frequency of use of Chinese medicine: Chishao- Yinchen, Danshen- Yinchen, Chishao- Danshen, Bazhu- Yinchen, Bazhu- Chishao, Yinchen-Dahuang, Bazhu- Danshen, Chishao- Dahuang, Danshen- Dahuang, Yinchen-Yiyiren.(2) Most pharmaceutical categories of HBV-ACLF patients: Diuresis Shenshi medicine, antipyretic medicine, tonic medicine, blood circulation medicine, qi medicine, dampness medicine, relieving drugs; the most common Top 10 groups of the Chinese medicine compatibility: Antipyretic medicine-Diuresis Shenshi medicine, antipyretic medicine-antipyretic medicine,Diuresis Shenshi medicine-Diuresis Shenshi medicine, antipyretic medicine-tonics medicine, Diuresis Shenshi medicine-tonic medicine,antipyretic medicine- blood circulation medicine, Diuresis Shenshi medicine- blood circulation medicine, diuresis Shenshi medicine- dampness medicine, antipyretic medicine- dampness medicine, antipyretic medicine- qi medicine.(3) in patients with HBV-ACLF(frequency > 100) drug commonly used medicinal properties are: bitter, sweet, cold, cold, warm, light, oct.(4) HBV-ACLF patients commonly used drugs Meridian(frequency> 1000)are: spleen, stomach, lung, liver, heart sutra; Commonly used drugs to the compatibility(top 5 groups of frequency) : the spleen- stomach, spleen, lung, lung, stomach, spleen, liver, lung, liver.(5)the most core medicine of Yang Huang syndrome: Chishao, Yinchen, Danshen and Huzhang; the top ten Chinese medicine and its effectiveness are: Yiyiren, Bazhu, Shichangpu, Yujin,Dahuang,Wumei, Huashifen, Doukou, Huangqin, Tongcao, Huanglian. The most core medicine of Yin Yang Huang syndrome : Danshen, Yiyiren,Yinchen, Baizhu, Chishao; the top ten Chinese medicine and its effectiveness are:Huzhang,Dahuang, Wumei, Yujin, Gegen, Fuzi, Shichangpu,Zhiqiao,Fuling, Huangqin, Huangqi. The top ten Chinese medicine and its effectiveness of Yin syndrome: Fuling, Wumei, Dahuang,Yinchen, Shichangpu, Yujin,Huashifen, Chishao, Huangqin, Danshen; because of small cases of Yin Huang syndrome,we could not sumrise the core medcine, we need more data to study in future.Conclusions: 1.Based on the data mining techique,we concluded the Chinese Medicine syndrome regulation of HBV-ACLF,which was basically in correlation of the "Yang Huang- Yin Yang Huang- Yin Huang " syndrome Differentiation Standard. 2. The whole core prescription medicine of are Yinchen, Chishao, Danshen, Baizhu, Yiyiren and Dahuang;the core prescription medicine of Yang Huang syndrome are Chishao, Yinchen, Danshen and Huzhang. The core prescription medicine of Yin Yang Huang syndrome are Danshen, Yiyiren, Yinchen, Baizhu and Chishao.We can make up our own prescription by the judgement of patients' sydrome symptoms and the Chinese medicine four diagnostic to increase or decrease medicine;at the compatibility of medicine, we usually chose Diuresis Shenshi medicine, antipyretic medicine, tonic medicine,and blood circulation medicine;at the channel tropism,we usually chose the spleen channel and stomach channel medicine,which means we lay emphasis on the use of "Ganbing Shipi " method. 3. The use of " TCM clinical research information integration platform " and data mining technology, by the research of HBV-ACLFsyndromes distribution characteristics and its treating and drug regularity, providing a reference for the establishment of the standardization and regulation of TCM treatment model, and the basis of TCM differentiation and treating of liver plague. |
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