The Clinical Observation Of Wuwei Xiaodu Yin On Treating The Drug Eruption Caused By EGFR-TKI

Objective:Observating the clinical efficacy of Wuwei Xiaodu Yin on the rash caused by epidermal growth factor receptor tyrosine kinase inhibitors The observation includes the affection taken by Wuwei Xiaodu Yin on the TCM symptomatic score, quality of life and the grade of the rash and the safety assessment about Wuwei Xiaodu Yin.EGFR-TKI which mainly are erlotinib and gefitinib.Method:The selected 71 patients from Wards and outpatient oncology hospital affiliated to Chengdu University of Traditional Chinese Medicine with rash which caused by taking erlotinib or gefitinib were randomly divided into 2 groups,36 cases in the treatment group,35 cases in the control group.The patients who are non small cell lung cancer from 2013 June-2014 year in October from the use of EGFR-TKI. The treatment group was treated by Wuwei Xiaodu Yin and the control group was given Calamine Lotion to treat.Two groups of patients underwent two cycles (a total of four weeks) treatment.before and after treatment, we evaluated the grading of the rash according to the NCI-CTCAE V4.0,the TCM symptom scores, and the quality of life according to the DLQI (Dermatology Life Quality Index). After the observation, we used SPSS 17.0 to analyze the statistics.Results:The treatment group and the control group at the end of treatment symptom scores both decreased. The total effective rate in treatment group Was 94.44% and in control group the total efficiency was57.14%Results in the two groups had significant difference (P< 0.01). After therapy, the quality of life score and the grading of the rash had improved in both the treatment group and the control group and statistics showed significant difference (P< 0.01). Between the two groups after treatment,those aspects had significant difference (P< 0.01) and the treatment group was better than the control group.Clinical observation:1.The Wuwei Xiaodu Yin has Better effect on the rash caused by epidermal growth factor tyrosine kinase inhibitor, and has a better effect than the control group;2. The Wuwei Xiaodu Yin on the life quality of the patients improved significantly, which is superior to control group.3. The Wuwei Xiaodu recipe has good safety...