The Clinical Observation Of Jiawei Pipa Qingfei Yin On Treating The Rash Caused By Egfr-tki

Objective:Observating the clinical efficacy of Jiawei Pipa Qingfei Yin on the rash caused by epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) which mainly are erlotinib and gefitinib. The observation includes the affection taken by Jiawei Qingfei Yin on the TCM symptomatic score, quality of life and the grade of the rash and the safety assessment about Jiawei Qingfei Yin.Method:the selected61patients with rash which caused by taking erlotinib or gefitinib were randomly divided into2groups,31cases in the treatment group,30cases in the control group. The treatment group was treated by Jiawei Pipa Qingfei Yin and the control group was given minocycline to treat. Two groups of patients underwent two cycles (a total of four weeks) treatment. Before and after treatment, we evaluated the TCM symptom scores, the grading of the rash according to the NCI-CTCAE V4.0(Common Terminology Criteria for Adverse Events Version4.0published by National Institutes of Health) and the quality of life according to the DLQI (Dermatology Life Quality Index). After the observation, we used SPSS17.0to analyze the statistics.Results:The treatment group and the control group at the end of treatment, symptom scores both decreased. The total effective rate in treatment group was80.64%and in control group the total efficiency was63.33%. Results in the two groups had significant difference (P<0.01). After therapy, the quality of life score and the grading of the rash had improved in both the treatment group and the control group and statistics showed significant difference (P<0.01). Between the two groups after treatment, those aspects had significant difference (P<0.01) and the treatment group was better than the control group.Conclusion:1. The Jiawei Pipa Qingfei Yin has remarkable curative effect on the rash caused by epidermal growth factor tyrosine kinase inhibitor, and has a better effect than the control group;2. The Jiawei Pipa Qingfei Yin can make a great improvement on the quality of life of patients, and is better than the control group;...