The Study On The Treatment Of Cervical Intraepithelial Neoplasia Of HR-HPV Infection By Combination Of Lactobacillus

Objective: To investigate the feasibility of the interferon and vagina use lactobacillus element capsule to treat the cervical HR-HPV infection, to provide the scientific basis for prevention and treatment of cervical cancer. Methods: collected the women aged 30-59 who was in the treatment at Xinjiang production and construction corps hospital and high-risk type infection HPV through HC-2 check from June 2012 to December 2012, at the same time, through the cervical liquid based cytology and colposcopy biopsy pathological examination it was made a definite diagnosis that it was cervical neoplasia ?level(CIN?) [1] outpatient follow-up patient was 167 cases. In the research, the patients entering into the treatment group was 98 cases, the control group was 69 cases. The treatment group used interferon(interferon ? suppository) and vagina use lactobacillus element capsule(Aopingshuan), and vaginal used lactic acid bacteria capsule(Living preparation of lactobacillus) vaginal medication every other day, and separation separate the interval of the two drugs, and stop drug in the menstrual period, and the total drug use monthly is 20 days;A group of natural follow-up: Stop drug during menstrual period. After the treatment group used the group for 4 menstrual periods, made the subsequent treatment intervention according the vagina internal environment. Except follow-up visit,the control group did not make any intervention. The patients of two groups were follow-up clinic after the cleaning of the menstruation in the 4?6?12?24 months, and rechecked the various indicators, to compare the patients' symptoms, HPV overcast turned tonegative and made the drop degrees, TCT, colposcopym and endovaginal environment.Results: After 4 mouths of treatment,the control group,combined treatment group,the reversal rate of CIN?:20.64%?29.58%?38.78%; After 6 mouths of treatment,the control group,combined treatment group,the reversal rate of CIN?:33.33%?47.06%?52.63%;After 12 mouths of treatment,the control group,combined treatment group,the reversal rate of CIN?:38.33% ? 56.92% ? 73.12%; After 24 mouths of treatment,the control group,combined treatment group,the reversal rate of CIN?:51.85%?70.00%?85.39%;At 12 mouths,and at 24 mouths,the revesal rate of CIN?was significantly higher that in the control group,P<0.05. After treatment of 4 mouths, the control group, interferon group,combined treatment group HR-HPV negative rate was28.99%?40.58%?61.22%;After treatment of 6 mouths, the control group, interferon group, combined treatment group HR-HPV negative rate was37.88%?53.03%?73.69%;After treatment of 12 mouths, the control group, interferon group, combined treatment group HR-HPV negative rate was50.00%?67.69%?86.02%;After treatment of 24 mouths, the control group, interferon group, combined treatment group HR-HPV negative rate was66.67%?83.33%?94.38%;Interferon group and combined treatment group in each follow-up time period of HR-HPV negative rate was significantly higher than those of control group, with statistical significance,P<0.05.In12 mouths, 24 mouths combined treatment group HR-HPV negative rate compared with interferon group also increased significantly, with statistical significance,P<0.05.Conclusions:1.Interferon combination vagina lactobacillus vagina calm environment can promote the reversal of CINI,extended over time, the role of the more obvious.2.Interferon can increase the clearance rate of cervical HR-HPV, tide to,but through the combined use of vaginal lactobacilli after stable environment of the vagina HR-HPV clearance rate and removal rate is higher.3.After lactobacillus adjustmen vaginal environment, environment of the vagina and vaginal cleanness, vaginitis morbidity decreased obviously.For vagina lactobacillus with interferon therapy HR-HPV infections of CINI is always kind of curative effect is distinct,convenient and safe treatment method,worthy of clinical popularization and application.