| Objective To analyze the potential association between vascular endothelial growth factor gene polymorphisms with the risk of idiopathic recurrent spontaneous abortion by Meta analysis.Methods Published case-control studies about the influence of VEGF polymorphisms on recurrent spontaneous abortion(RSA) were searched and screened in China National Knowledge Internet(CNKI)? Pubmed?Medline?the Cochrane library? data base of Weipu?database of Wanfang and Chinese Biological Medicine Disk(CBM). RevMan 5.3 software was used for meta-analysis.Results There were 11 literatures including 1945 RSA patients and 2074 control cases, which were eligible for the criteria to researching the VEGF polymorphisms about-634G/C (rs2010963)?+936C/T (rs3025039)?-2578C/A (rs699947) and-1154G/A(rs1570360).The results of meta analysis showed that the risk of RSA was higher in those with-634CC genotype than-634GG genotype[P=0.03, OR=1.29,95%CI(1.03,1.63)], in -634C allele than-634G allele[P=0.02, OR=1.14,95%CI(1.02,1.27)].The risk of RSA was higher in those with+936CT and+936TT genotype than +936CC genotype[CT vs CC genotype:P< 0.0001, OR=1.40,95%CI(1.18,1.65), TT vs CC genotype:P= 0.02, OR=1.72,95%CI(1.11,2.66)], and also in allele+936T than+936C[P< 0.00001, OR=1.52,95%CI(1.30,1.78)].There were no evidences for association between RSA and the VEGF-2578C/A and-1154G/A gene polymorphisms in the genotype or allele frequencies distribution(P>0.05).Conclusion The VEGF-634G/C (rs2010963) and+936C/T (rs3025039) gene polymorphisms may be associated with the risk of idiopathic recurrent spontaneous abortion... |
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