| Objective:To study the clinical effects of combining ningjing particles and meridian scraping to treat liver-fire depression generalized anxiety disorder and provide relevant basis for further optimizing the diagnosis and treatment regimen of traditional Chinese medicine(TCM).Methods:Divided 90 cases of liver-fire depression generalized anxiety disorder patients into three groups:group A,B and C.Group A was treated with meridian scraping method and given oral ningjing particles at the same time,group B was given only oral ningjing particles while group C was given oral Flupentixol/Melitracen tablets(Deanxit)with 28 days' treatment.Recorded in detail the age,gender,course of disease,visual analog scales(VAS)score,TCM symptom score,hamilton anxiety(HAMA)scale score and Pittsburgh sleep quality index(PSQI)score of each patient.Observe the VAS score,TCM symptom score,HAMA scale score and PSQI score before treatment of patients in the three groups.In addition,assess the efficacy and safety of medicine.Results:1,VAS score and TCM symptom score:the VAS and TCM symptom score of the patients in the three groups after treatment all dropped compared with those before treatment(P<0.05).The improvement of symptoms in group A was better than that in group B and C(P<0.05)while the efficacy of group B and C were neck and neck(P>0.05).2,Analysis on HAMA scale score:among the 90 cases in the three groups,25 cases clinical recovered and 7 cases were ineffective,resulting to a clinical recovery rate of 27.78%and an overall response rate(ORR)of 92.22%.In group A,14 cases clinical recovered,11 cases effective,3 cases improved and 2 cases ineffective,resulting to a clinical recovery rate of 46.67%and an ORR of 93.33%;In group B,6 cases clinical recovered,13 cases effective,9 cases improved and 2 cases ineffective,resulting to a clinical recovery rate of 20%and an ORR of 93.33%;In group C,5 cases clinical recovered,14 cases effective,8 cases improved and 3 cases ineffective,resulting to a clinical recovery rate of 16.67%and an ORR of 90%.Upon examination,the ORR in the three groups had no statistical differences(P=0.665>0.05).Through pair wise comparison,the mutual efficacy among two groups also had no statistical differences.It was indicated that the overall efficiency in the three groups were consistent.Through chi-square analysis,the clinical recovery rate in the three groups had statistical differences(P=0.018<0.05).Through pair wise comparison,the clinical recovery rate between group A and B had statistical differences(P=0.027<0.05)and the clinical recovery rate between group A and C had statistical differences(P=0.013<0.05)while the clinical recovery rate between group B and C had no statistical differences(P=0.5>0.05).It was indicated that the clinical recovery rate of group A was not only higher than that of group B but also than that of group C.3,Analysis on PSQI score:the PSQI score of patients in the three groups after treatment all dropped compared with that before treatment(P<0.05)and the improvement of symptoms in group A was obviously better than that in group B and C when the patients were treated for 2 weeks,which had significant statistical differences(P<0.05).The score of the three groups were obviously improved compared with that before treatment when the patients were treated for 4 weeks and the improvement of symptoms in group A was obviously better than that in group B and C(P<0.01)while there were no statistical differences between group B and C(P>0.05).In the three groups,a total of 18 cases were cured with 17 cases ineffective and the recovery rate was 20%while the ORR was 81.11%.In group A,10 cases were cured and 2 cases were ineffective with a recovery rate of 33.33%and an ORR of 93.33%;In group B,5 cases were cured and 6 cases were ineffective with a recovery rate of 16.67%and an ORR of 80%;In group C,3 cases were cured and 9 cases were ineffective with a recovery rate of 10%and an ORR of 70%.Upon examination,there existed statistical differences in the ORR of the three groups(P=0.007<0.01).4,During treatment,one case in group A and 2 cases in group B developed adverse reactions,which mainly took the form of such gastrointestinal symptoms as dominated by nausea and mild diarrhea.After ordering the patients to take medicine for several times,these symptoms disappeared.4 cases in group C developed adverse reactions,which mainly took the form of dry mouth,sweating and itchy rash.Conclusions:1.Ningjing particles can improve the clinical symptoms of liver-fire depression GAD and are an effective prescription to treat liver-fire depression GAD.2.The curative effect of combining ningjng particles with meridian scraping is better than that of only using quiet particles and such combination can better improve the anxiety symptom of liver-fire depression GAD patients than Deanxit.3.Less adverse reactions were found when using together ningjing particles with meridian scraping to treat liver-fire depression generalized anxiety disorder,.which had good safety. |
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