| Objective:To study the changes of microflora, serum levels of procalcitonin(P CT) and C-reactiveprotein(CRP) in patients with colorectal cancer, discuss the relati onship with changes of microflora,PCT and CRP.Method:Selected 68 patients with benign colonic diseases proved by microscopic examination subjects and pathology as the case group,32healthy volunteers as control group,fresh faces samples were c ollected,Bifidobacterium and Enterobacteriacase were cultured quantitatively by the method established by Mit-suoka,we also calculated the B/E value (the ratio of Bifi dobacterium to Enterobacteriacase),which is used to evaluate changes of intestinal microflora.2.Collected serum samples of all subjects,we detected serum levels of PC T and CRP.Results:1.Changes of intestinal flora:Compared with the control group,t he number of Enterobacteriacase of the case group increased significantly(P<0.05),B ifidobacterium decreased significantly(P<0.05),and B/E value lower significantly(P<0. 05),3.Serological makers:Compared with the control group,the case group serum lev els of PCT and CRP increased significantly(P<0.05).3.Correlation analysis:There was significant negative correlation between B/E and PCT and CRP,the B/E value assoc iated with the PCT is strang(r=-0.73,P<0.01),the B/E value associated with theRCP is strang(r=-0.71,P<0.01).Conclusion:1.Patients with colorectal cancer exists the ph enomenon of intestinal dysbacteriosis,2.CRP and PCT in colorectal cancer group we re higher than the healthy control group, suggesting that CRP and PCT were correl ated and colorectal cancer.3.CRP and PCT in colorectal cancer group and B/E valu es of correlation analysis found that CRP and PCT and B/E values are correlated,s uggesting that the intestinal flora of colorectal cancer to participate in colorectal ca ncer progression by inducing inflammatory mechanism may be reaction in order to promote the occurrence and development of colorectal cancer. |
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