Non-enzymatic Glucose Sensors Based On A Nanowair Array Strategy Of Pd And Ni Composites

Diabetes is a metabolic disorder and becomes a world health problem.It causes manycomplicationssuch as heart disease, kidney failure, neuropathy, foot ulcers, and even blindnessonce lost to control, because of which it becomes one major factor leading to death anddisability in the world. Diabetes is incurable nowadays, but the complications incidencecan begreatly reduced through strict controlling of personalblood sugar levels, which makes thefrequent determination of glucose as the most direct means for monitoring patients condition.Therefore, Strict monitoring and effective detectionof blood sugar is of great clinicalsignificance.Currently, non-enzymatic glucose sensors attract more and more interests of scientificworkers. Due to its large specific surface area and easily to transform into active NiO(OH),Ni-based nanomaterial display high catalytic activity for glucose electrooxidation. Palladiumnanomaterial exhibits excellent anti-poisoning ability towards glucose oxidation and goodcatalytic activity with very large S/V ratios.Therefore,it is believed that the combination ofboth Pd and Ni metals as bi-metallic catalysts can improve their sensor application.Based onthe recent research and a nanowire array strategy, we used PdNWAs as the carrier of Ninanoparticals to fabricate a novel glucose sensor. And then fabricated PdNi bi-metallicnanowire arrays for glucose electrochemical detection.In Chapter2, PdNWAs are fabricated by AAO template technology and Ni nanoparticalswas successfully coated on the surface of Pd nanowires by pulse electrodeposition method.The resulted Ni/PdNWAs is used for amperometric sensing of glucose in alkaline electrolyteand shows significantly improved electrochemical performancewith a low detection limit (0.5μM, s/n=3) and wide linear range from5μM to8.565mM (R2=0.995).Furthermore, thesensor exhibits good selectivity ability, a very good reproducibility and high long-termstability.In Chapter3, PdNi bi-metallic nanowire arrays are fabricated by electrodepositionmethod and are used for glucose electrochemical detection. Applied potential, the percent ofcomposites of the nanowires and deposition time all have effect on glucose current response.Glucose sensing performed better on this material with a wider linear range and a lowerdetection limit than reported Pt/Ni bi-metallic nanowire arrays, and the sensitivity for glucoseon this material is510more times than pure Pd nanowire arrays. Further more the PdNinanowire arrays performed an excellent selectivity of glucose.