| As a necessary component of life,the rapid and reliable detection of glucose concentration is very essential for the production and life of society.Up to now,glucose sensors have been developed for four generations,the first three generations are the sensors based on the biological enzyme,but they suffer from the inherent shortcomings of biological enzymes,and the enzymes sensors require very demanding environment,which greatly limits the development of enzyme-based glucose sensors.Thus,the fourth generation of non-enzymatic glucose sensor emerges as the times require.In recent years,there have been a large number of reports on non-enzymatic glucose sensors,which are mainly composed of various metals,metal oxides and their composite materials,because of the low price and excellent electrocatalytic properties of metal oxides,the materials based on transition metal nickel and copper have attracted widespread attention.Therefore,in this paper,the nickel and copper oxides nanomaterials were taken as the research object to construct the non-enzymatic glucose sensor,and the physicochemical properties of these as-prepared nanomaterials were characterized by XRD,SEM,EDS and AFM furthermore,the electrochemical properties of the sensors for glucose detection was investigated by cyclic voltammetry and chronoamperometry.In this dissertation,we focused on following researches:?1?The flower-like nickel oxide ultrathin nanosheet was synthesized by solvothermal method under the action of template P123.With the special micro-morphology,the specific surface area of nickel oxide increases,and the contact area with glucose become larger,which can provide more electrons to participate in the reaction during the electrochemical detection of glucose,so that the non-enzymatic glucose sensor constructed by the nickel oxide has a sensitivity of up to 2550.693 ?A·cm-2·mM-1,while still having good selectivity.?2?The nano-layered copper oxide was synthesized by microwave-assisted method,then the as-prepared material was modified on a glassy carbon electrode to construct a non-enzymatic glucose sensor.As the surface of the nano layer is smooth,the contact area with glucose is large during the electrochemical reaction,which makes a short reaction time.The sensor has a sensitivity of 2491.236 ?A·cm-2·mM-1,besides,it shows good selectivity and excellent anti-toxicity,however,the detection range of the sensor is relatively narrow.?3?The raspberry-like copper oxide nano-material with fine protrusions on the surface protrusions was synthesized by solvothermal method under the action of template P123.The morphology greatly increases the specific surface area of copper oxide,and the active site of the copper oxide increases as well,which makes a larger contact area between glucose and copper oxide during the electrochemical detection of glucose,leading a more rapid reaction.Therefore,the non-enzymatic glucose sensor constructed by the copper oxide has a sensitivity 2810.01 ?A·cm-2·mM-1,and the electrochemical detection for glucose can be performed on a wide concentration range of 179 nM to 6.5 mM,besides,the detection limit is as low as 59 nM.Moreover,the sensor has good selectivity while the influence of chloride ion can be negligible.In summary,this paper mainly studied the use of nickel oxide and copper oxide as sensitive materials for electrochemical detection of glucose,and concluded that the raspberry-like copper oxide nano-material prepared by solvothermal synthesis method has the most excellent properties,which provides a new idea for rapid and sensitive detection of glucose. |
PDF Full Text Request