Chronic Obstructive Pulmonarydiseases And Risk Of Lung Cancer Among Men And Women Nonsmokers:A Metaanalysis

Objective :To provide evidence for decision-making on lung cancer prevention through studying the risk between chronic obstructive pulmonary diseases and lung cancer among nonsmokers.Methods:A literature search was conducted in Pub Med,VIP,CNKI and Wang Fang to select the relevant publications on the association between chronic obstructive pulmonary diseases and lung cancer among nonsmokers. Quality of related literatures was reviewed and software of Review Manager 5.3 was uesd to conduct Meta analysis.Results:9 studies(2 089 cases and 4 519 controls)were identified.The morbidity rate of chronic obstructive pulmonary diseases was significant different between lung cancer patients and controls,the pooledodd ratio was1.46(95%CI=1.26~1.70). Subgroup analysis shows,the difference was obvious in White(OR=1.58;95%CI=1.20~2.08),but there is no statistical difference in Asian(OR=1.25;95%CI=0.98 ~1.59).And subgroup analysis shows,COPD was significantly associated with the odds for increased risk of lung cancer( OR=1.46;95%CI=1.04~2.03),so were chronic bronchitis(OR=1.64;95%CI=1.15 ~ 2.36) andemphysema(OR=1.47;95%CI=1.17 ~1.83).Conclusion:This result suggests the morbidity of chronic obstructive pulmonary diseases is probably associated with lung cancer expect smoking.