| Objective: Our retrospective study was aimed to observe the thyroid hormone levels in patients with primary nephrotic syndrome, and to investigate the effect of PNS on thyroid function and clinical significance.Methods: Clinical data of 22 patients with PNS received treatment at our hospital, including 7 patients with normal thyroid function(normal group) and 15 patients with abnormal thyroid function(abnormal group). 20 healthy persons at the same time at our hospital were chosen as the control group. The thyroid function between control group and PNS group,the clinical information and the renal pathological type between normal group and abnormal group were compared. The relationship between thyroid function and ALB, 24 h PRO, TG, TC, LDL-C, HDL-C),SCr,Urea were correlatively analyzed.Results: 1.The thyroid function of controll group was normal,and the rate of patients with abnormal thyroid hormone in PNS group was 68.2%(15/22),with TSH rise, FT3 and FT4 decreased(P<0.05). 2. The levels of FT3 and FT4 in abnormal group were lower than those in normal group(P<0.05), and the levels of Urea in normal group were lower than those in abnormal group(P<0.05). The levels of ALB in controll group were higher than those in abnormal group, and the levels of TG,TC,LDL-C,Scr and Urea in controll group were lower than those in abnormal group(P<0.05). 3. The levels of Scr,Urea in normal group were lower than those in abnormal group, and the levels of FT3 in patients with primary nephrotic syndrome had negative correlation with Scr,Urea(P<0.05). The relationship between FT4,FT3,TSH and ALB,24 h PRO, TG, TC, LDL-C,, HDL-C were not obvious(P>0.05). 4.The renal pathological type in normal group and abnormal group had no statistical difference(Fisher exact test2?=5.068,P=0.240).Conclusion: The thyroid hormone of patients with PNS is usually abnormal, which with TSH rise, FT3 and FT4 decreased. The level of FT3 in patients with primary nephrotic syndrome has negative correlation with Scr,Urea. |
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