Study Of The Impact Of Trace Elements And Depression And Anxiety On Recurrent Aphthous Ulcer

Objective:To research and analyze the impact of levels of trace elements such as zinc,copper,iron and magnesium and the degrees of depression and anxiety on recurrent aphthous ulcers in order to explore their causes and therefore provide new methods for clinical treatment.Methods:1.Two groups of data are collected: the first group of data is collected from 30 patients who were diagnosed with Minor RAU. These are the patients who visited the First Hospital of Shanxi Medical University between July 2015 and December 2015.This group is referred to as the experimental group. Over the same period of time, the second group of data is collected from 25 volunteers who are hospital students and staff with no symptoms of RAU. This group is referred to as the control group. The levels of trace elements such as zinc,copper,iron and magnesium in the blood serum of both groups is checked by using atomic spectrum absorption method, five channel atomic absorption spectroscopy.2.Both groups filled in a questionnaire individually on the self–rating Anxiety Scale(Self-Rating Anxiety Scale) and the self-rating Depression Scale(Self-Rating Depression Scale)to record anxiety and depression scores.3.Both groups went through comprehensive oral examination, and the data obtained are analyzed with SPSS 19.0statistics software.Results:1.The analysis showed that the trace elemental zinc level in the experimental group is lower than that in the control group. The difference is statistically significant in the experimental group(P < 0.05), and female patients has a lower zinc level than male patients. The difference is statistically significant(P < 0.05); however, comparing the two groups, the levels of copper, iron and magnesium are not statistically different(P >0.05).2.Anxiety and depression scores show that these are higher in the experimental group than in the control group, and the difference is statistically significant(P < 0.05).Pearson correlation analysis shows that in the experimental group, the zinc level and anxiety SAS score show a negative correlation, with statistical significance(P < 0.05);also the zinc level and SDS score are negatively correlated with statistical significance(P< 0.05). In the experimental group female patients’ anxiety SAS scores are higher than male patients’,and the difference are statistically significant(P < 0.05), while there is no statistical difference in depression SDS scores(P > 0.05) between these two genders.3.Binary logistic regression analysis shows there are three statistically significant variables(P<0.05):Zn(OR=0.959,95%CI:0.920-0.999,P=0.046),SAS(OR=1.333,95%CI:1.075-1.654,P=0.009) and SDS(OR=1.161,5%CI:1.002-1.346,P=0.047). By analysing the OR value, it can be deduced that the trace element Zn is a protective factor, while anxiety and depression are risk factors for the disease.Conclusions:1.The occurrence of RAU is related to the decrease of zinc content in the patients.2.RAU is correlated with anxiety and depression.3.Trace element zinc levels and anxiety and depression correlate negatively in RAU patients.