| Background:Coronary heart disease and depression are both common chronic diseases. The incidence of coronary heart disease and depression showed an increasing trend, and have become a severe public health problem. Depression is one of coronary heart disease patients are often combined psychological barrier. The present study has prove that depression is one of the major risk factors of coronary heart disease, and adversely affect the development and prognosis of coronary heart disease. At the same time, Coronary artery disease in patients with high incidence of depression in the general population. The same changes in the pathogenesis of coronary heart disease and depression, suggest the presence of common pathophysiology. Serotonin (5-HT) is both platelet activating factor and vasoconstrictor agents, but also inhibitory neurotransmitter. Studies have demonstrated that the current 5-HT has played an important role in the pathogenesis of coronary heart disease and depression, and is considered to be one of the pathogenesis of coronary heart disease with depression. Coronary heart disease and depression are polygenic. Common genetic mechanism of coronary heart disease with depression is unclear. Currently there are more than speculation genes may play a role in coronary heart disease and depression.5-HT by the serotonin transporter (5-HTT) regulation. The 5-HTT is affected by 5-HTT gene. Therefore, some scholars believe that 5-HTT gene is one of the genetic factors of coronary heart disease with depression. Tests confirmed that there is a connection between them, but lack of evidence-based medical evidence to support.Objective:Collect randomized case-control studies that have been published about the serotonin gene polymorphism and coronary heart disease and depression. To evaluate the associations of 5-HTT gene polymorphism with depression and coronary heart disease by meta-analysis and provide evidence for the genetic background of coronary heart disease and depression.Methods:A comprehensive search for articles from PubMed, Google Scholar, Web of Science, Chinese BioMedical Literature, CNKI databases and Wanfang databases. We make the OR value as the effective Index.Genotypes in the control group were consistent with Hardy-Weinberg genetic equilibrium law. We use the Cochrane risk of bias to evaluate the quality of each one met the inclusion criteria of the literature.It includes:Random sequence generation, allocation concealment, implementation and participants blinded outcome assessment blinding, incomplete outcome data, published and other factors may lead to bias. All related case-control studies were collected and the results were analyzed using RevMan 5.2.5 software. While the publication bias are analyzed by the funnel plot.Results:A total of 1179 cases and 2051 controls were collected from 3 studies. We analyze the relationship between serotonin SS、SL and LL three genotypes with coronary heart disease and depression by meta-analysis. The analysis of relationship between SS genotype with coronary heart disease and depression shows:Z-=39, P=0.7.The difference has no statistical significance. The analysis of relationship between SL genotype with coronary heart disease and depression shows: Z=1.80,P=0.07.The difference has no statistical significance. The analysis of relationship between LL genotype with coronary heart disease and depression shows:95%C/0.65 (0.50-0.83),Z=3.44,P=0.0006.The difference has statistical significance. The funnel plot shows there is no significant publication bias.Conclusions:Polymorphisms of 5-HTT gene have association with the depression and coronary heart disease, LL genotype may be protective factors for the depression and coronary heart disease. |
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