The Association Between HIF-1? Gene 1772C/T Polymorphism And Coronary Collateral Circulation In Patients With Coronary Heart Disease: A Meta-analysis

Objective: To evaluate the association between hypoxia inducible factor-1?(HIF-1?)gene 1772C/T polymorphism and coronary collateral circulation in coronary heart disease(CHD)patients.Methods: A literature search was conducted using PubMed,the Cochrane Library,CNKI,CBM,VIP and Wanfang databases until January2017.Odds ratios(OR)and 95% confidence intervals(CI)were calculated using Stata version 12.0 software.Results: A total of 5 eligible articles including 1355 subjects were analyzed.We found no significant association between HIF-1? gene 1772C/T polymorphism with coronary collateral formation in CHD patients in the all genetic models.(allele model:T vs C:OR=1.70,95%CI:0.85-3.39,P=0.134;Dominant model:TT+TC vs CC,OR=1.46,95%CI: 0.77-2.77,P=0.251;Recessive model:TT vs TC+CC,OR=1.73,95%CI: 0.75–3.99,P=0.197;Homozygote model:TT vs CC,OR=1.73,95%CI:0.74-4.03,P=0.204;Heterzygote model:TC vs CC,OR=1.00,95%CI:0.72–1.37,P=0.988).Conclusions: HIF-1? gene 1772C/T polymorphism is not associatedwith coronary collateral formation in CHD patients.