Analysis On Correlation Between SYNTAX Score Of Coronary Aretery And Fibrinogen And Glycosylated Hemoglobin

Objective:This study analyzes the degree of glycosylated hemoglobin and fibrinogen between cases with coronary artery heart disease and without coronary artery heart disease,inorder to make it clear that wether these two indicators has a correlation with the risk of coronary heart disease. Then combine with the SYNTAX score of the coronary heart disease patients, analyzing the correlation between glycosylated hemoglobin and fibrinogen with the coronary artery lesion and think about the value of glycosylated hemoglobin and fibrinogen in clinical diagnosis and therapy in CHD.Methods:Selected the patients that hospitalized in Shanxi Medical University the First Hospital Department of cardiology during 2014.11 ~ 2016.01, all the patients mainly complain of symptoms of angina, have similar medical history or the ECG indicated myocardial ischemia. All the cases made required examination and signed informed consent before examined by coronary arteriography(CAG), a total of 120 cases were into the study, including 78 male datas and 42 female datas, 90 coronary heart disease patients have been diagnosed with coronary arteriography examination and 30 patients without CHD. Patients have a history of percutaneous coronary intervention(PCI)or coronary artery bypasses grafting(CABG)have been eliminated. Other conditions such as acute myocardial infarction,serious heart failure,secondary hypertension, dilated cardiomyopathy, hypertrophic cardiomyopathy, serious functional disturban of liver kidney and brain, malignant tumor,autoimmune disease, blood disease, coagulation disorders,thyroid disease, type 1 diabetes, acute or chronic infectious disease, take glucocorticoid recently, take operation or have a trauma recently, gestation or lactationhypersensitivity to iodinatedcontrast media, ambiguity medical history have been eliminated as well. Use the SYNTAX scoring system to value the degree of coronary artery lesions of CHD patients, according to the scores they could be divided into three groups: low risk group(n=46, 1—22 scores), intermediate risk group(n=34, 23—32scores)and high risk group(n=10, ≥33 scores). Record the glycosylated hemoglobin and fibrinogen level and other clinical datas of all the patients. Use the SPSS18.0 software to make an analysis of the datas, the difference was statistically significant(P<0.05).Results:1. Compared the datas between CHD group and control group, we can see the difference of Hb A1 c, FBG, Fg, TC was statistically significant(P<0.05), and the age,gender, BMI, TG, UA, HDL-C, LDL-C, with or without hypertension and smoking history have no significant difference between these two groups(P>0.05).2. Campared the datas between the three groups divided according to the SYNTAX score of CHD patients, we find that Hb A1 c, Fg, LDL-C have a statistically significant difference between the different level of the scores(P<0.05), while the rest of the factors have no statistically significant difference between the three groups(P>0.05).3. Through the Pearson correlation analysis, we find that Fg has a strong correlation with the SYNTAX score(r=0.768,P<0.05), Hb A1 c has a strong correlation with the SYNTAX score(r=0.738,P<0.05), although LDL-C also has a statistically significant difference, the correlation with the SYNTAX score is weak(r=0.231,P<0.05).Conclusion:1. Hb A1 c and Fg have a correlation with the occurrence of coronary heart disease and can predict the prevalence risk of CHD to some degree.2. Hb A1 c and Fg have a positive correlation with the degree of coronary artery lesions, with the increase of the two levels, the degree of coronary artery lesions will become serious. Strictly control the levels of Hb A1 c and Fg may have certain clinical significance.