The Level Detection And Clinical Significance Of Plasma P53 Protein And COX-2 In Patients With Gastric Cancer In Qinghai

Objective: To detecte the levels of p53 protein and COX-2 in the plasma of 60 patients with gastric cancer and 50 healthy persons in Qinghai and study the effects of p53 protein and COX-2 on the development of gastric cancer.Methods: The plasmas from patients and healthy persons in Affiliated Hospital of Qinghai University,The plasma levels of p53 protein and COX-2 were determined using enzyme linked immunosorbent assay(ELISA). Results: 1.The levels of p53 protein in GC group and normal control group were 34.35±6.24(ng/ml)、16.04±4.41(ng/ml), GC group was significantly higher than that in normal control group, the difference was statistically significant(P<0.05).2.The COX-2 levels in GC group and normal control group were 25.19±3.03(ng/ml)、4.69±1.67(ng/ml), GC group were significantly higher than those in normal control group, the difference was statistically significant(P<0.05).3.The levels of p53 protein and COX-2 in gastric cancer were significantly different in different tumor size, TNM stage, differentiation degree and lymph node metastasis(P<0.05). 4.The positive correlation between plasma p53 protein and COX-2 in the GC group(r=0.789, P=0.01).Conclusion: The plasma p53 protein and COX-2 levels were not related to gender and age and tumor size,but correlateded with TNM stage, differentiation degree and lymph node metastasis of gastric cancer.They may participate in the occurrence, development and metastasis of gastric cancer.Gastric cancer patients plasma p53 protein and cox-2 has obvious positive correlation, combined detection of plasma p53 protein and cox-2 may judge the progression and prognosis of gastric cancer has certain reference value.