The Clinical Features Of Mild Cognitive Dysfunction In The Inpatient Middle-aged And Elderly Type 2 Diabetes

Objective:To investigate the clinical features of mild cognitive dysfunction in the inpatient middle-aged and elderly type 2 diabetes.Methods:From October 2014 to December 2015, we collected 95 subjects, among which 67 were type 2 diabetic patients, who were recruited from the department of endocrinology of the second people’s hospital of Changshu and the second affiliated hospital of Soochow University. 28 subjects in the control group were recruited from the department of geriatrics of the second people’s hospital of Changshu. The age of diabetes group was(64.1± 9.2) and the age of control group was(60.8±8.5). Depression were excluded by using Hamilton depression scale(HAMD- 17). Simple mental state test(mini getting state examination, MMSE) questionnaire were used to assess the patients’ cognitive function. All the subjects received ultrasonic examination of carotid artery, fasting blood glucose, liver and kidney function and lipids. In diabetic patients, glycosylated hemoglobin, fasting C-peptide and postprandial C-peptide were measured. All the diabetic patients received the examination of ophthalmofundoscope. The difference of MMSE between two groups was tested. Logistic regression analysis was adopted to find the factors associated with cognitive function.Results:MMSE scores were significantly lower in type 2 diabetesgroup than the control group(24.37±5.28 vs. 27.79±1.87, P<0.05).The prevalence of mild cognitive dysfunction in type 2 diabetes group was higher than the control group(49.3% vs. 10.7%, P< 0.05). In the whole population, the univariate logistic regression analysis showed that impaired cognitive dysfunction was related with age, female, alcohol consumption, education degree and diabetes. Multivariate logistic regression analysis results showed that diabetes, education level, female and age were associated with cognitive impairment. In patients with type 2 diabetes, the univariate logistic regression analysis showed that the impaired cognitive function was related to factors with age, female and alcohol consumption, Multivariate logistic regression analysis results showed that female and age were significantly associated with cognitive impairment with type 2 diabetes.Conclusion:In these inpatient middle-aged and elderly population, the prevalence of MCI is higher in those with type 2 diabets. Diabetes, age, and female are related with MCI.