| Objective:To investigate the expression of early growth response gene- 1(Egr-1),NGFI-A binding protein 2(Nab2) and caveolin-1(cav-1), and explore its role in the formation of hypertrophic scar.Methods: 9 cases of normal skin tissue, 8 cases of flat scar tissue and 9 cases of hyperplasia scar tissue was collected during surgery in our department between December 2013 and March 2015. Undergoing regularly fixed, embedded and serially sectioned, the expression of Egr-1, Nab2 and cav-1 protein in 9 normal skin tissues, 8 flat-cicatrix tissues and 9 hypertrophic scar tissues were examined with immunohistochemistry SP method and were analyzed statistically.Results:The expression of Egr-1 in epidermal cells, fibroblasts, and vascular endothelial cells of hypertrophic scar was significantly higher than that in normal skin and flat scar tissue. The expression of Egr-1 was gradually increased in normal skin, flat scar tissue and hypertrophic scar. The distribution patterns of Nab2 and cav-1 in normal skin tissue, flat scar tissue and hyperplasia scar tissue were different from Egr-1. The expression of Egr-1 was gradually increased, while expression of Nab2 and cav-1 was gradually decreased..Conclusions:The expressions of Egr-1, Nab2 and cav-1 were closely related to the formation of hypertrophic scar, and the up-regulated expression of Egr-1 and the deficient expression of Nab2 and cav-1 may be the indicators of the progress of formation of hypertrophic scar. |
PDF Full Text Request