Association Of The ARL15 RS6450176 SNP And Serum Lipid Levels In The Jing And Han Populations

Background:The association of ADP-ribosylation factor-like 15 (ARL15) rs6450176 single nucleotide polymorphism (SNP) and serum lipid profiles has never been studied in the Chinese population. The present study was undertaken to detect the association of ARL15 rs6450176 SNP and several environmental factors with serum lipid levels in the Jing and Han populations.Methods:Genotypes of the SNP were determined in 726 unrelated subjects of Jing nationality and 726 participants of Han nationality in the Fangchenggang city,Guangxi Zhuang Autonomous Region,China.They were all randomly selected from our previous steatified(age and sex)randomized samples.The epidemiological investigation was carried out following internationally standardized methods.Basic epidemiologic information was collected with standardized questionnaire from all participants.Results:The genotypic and allelic frequencies of the SNP in Jing but not in Han were different between males and females (P< 0.001 and P< 0.05; respectively). The G allele carriers in Han had lower serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and apolipoprotein (Apo) B levels, and higher ApoAl/ApoB ratio than the G allele non-carriers (P< 0.05-0.01). The G allele carriers in Jing had lower serum TC, high-density lipoprotein cholesterol (HDL-C), ApoAl, ApoB levels and higher ApoAl/ApoB ratio than the G allele non-carriers (P< 0.05 for all). Subgroup analyses showed that the G allele carriers had lower TC and LDL-C levels in Han males; lower LDL-C and ApoB levels in Han females; lower ApoB levels and ApoAl/ApoB ratio in Jing males; and lower LDL-C levels in Jing females than the G allele non-carriers (P< 0.05-0.01). Multiple linear regression analysis showed that serum TC, LDL-C, ApoB levels and the ApoAl/ApoB ratio in Han; and TC, HDL-C and ApoA1 levels in Jing were correlated with the genotypes of the ARL15 rs6450176 SNP (P< 0.05-0.001). Serum lipid parameters were also associated with several environmental factors in both ethnic groups.Conclusions:This study showed that the associations of the ARL15 rs6450176 SNP and serum lipid levels were different between the Jing and Han populations and between males and females in the both ethnic groups. There may be a racial/ethnic-and/or sex-specific association of the ARL15 rs6450176 SNP and serum lipid levels.