Effect Of Laparoscopic Radical Gastrectomy On The Organism CRP And Insulin Resistance

Objectives:Comparing the difference of C-reactive protein(CRP) and insulin resistance(IR) after laparoscopic and open radical gastrectomy for gastric cancer, and to explore the effect of these two procedures on the organism CRP and insulin resistance.Methods:seventy-nine patients with gastric cancer were divided into two groups to receive laparoscopic surgery(n=42) or open surgery(n=37). The CRP levels were measured preoperatively and at 1,2,3 and 7 days after the operation. The fasting blood glucose(FBG) and fasting insulin(FINS) levels were measured preoperatively and at 1,3,7days after the operation. And insulin resistance index(HOMA-IR)was calculated using the homeostasis model assessment.Results:The operation time, blood loss, and postoperative hospital stay showed statistically significant difference between the two groups(P<0.05). Compared with the preoperative levels, the CRP levels in both groups were significantly increased on days 1,2,3, and 7 after the operation(.P<0.05), with the highest level occurred on day 2 postoperatively.The postoperative CRP levels on days 1,2, and 3 were significantly lower in the laparoscopic group than in the open surgery group(P<0.05). Compared with the preoperative levels, the FBG levels in both groups were significantly increased on days 1,3, and 7 after the operation(P<0.05), the FINS, HOMA-IR levels in both groups were significantly increased on days 1 and 3 after the operation(P<0.05). The postoperative FBG, FINS, and HOMA-IR levels on days 1 and 3 were significantly lower in the laparoscopic group than in the open surgery group(P<0.05).Conclusion:Laparoscopic radical gastrectomy can reduce the impact on the organism CRP and insulin resistance, which on inflammatory and insulin resistance is mild than open operation and facilitates the postoperative rehabilitation.