| ObjectiveSingle blind random control method are used to observe "qing gan an shen stitch"treat type something disturbing the curative effect of primary insomnia, explore "qinggan nerves" characteristics compared to conventional, estazolam group in the treatment of type something disturbing the superior effect of primary insomnia.Methods1 this study was selected in 68 patients, all of which meet the inclusion criteria from Guangdong Province Traditional Chinese Medical Hospital. The method of stratified and group random. Using SAS statistical software, according to the number of cases and three groups of 1:1 of the random proportion of random numbers generated by random grouping table. The sham acupuncture+AI our estazolam Group 15 cases, fall off in 3 cases; acupuncture +compound vitamin B group (15 cases), fall off in 3 cases; Acupuncture plus moxa our estazolam Group 34 cases,2 cases lost; the final completion of the patients with a total of 60 cases, which sham acupuncture+AI our estazolam group 29 cases; acupuncture+compound vitamin B group (n=29); Acupuncture plus moxa our estazolam group 31 cases.2、treatment methods:sham acupuncture group:Daily acupuncture non acupoint at a time before going to bed to give a grain of estazolam; acupuncture+estazolam group:Daily acupuncture once also given at bedtime 1 grain of estazolam. The treatment time was 4 weeks in each group.3、determine the efficacy of the method:1011 curative effect criteria:before and after the treatment were performed in Pittsburgh sleep quality index scale of measurement and detection. Second recurrence rate evaluation:treatment after the end of the third week and the sixth week follow-up, if the follow-up time point for the PSQI. At the end of the treatment, the SCORAD scores, depending on the recurrence.4、safety comparison:recorded in each group during the treatment of daytime sleepiness, dizziness, headache and other symptoms of discomfort.Results1 curative effect comparison:1.1 total effective rateThe total effective rate was 75%; sham acupuncture+estazolam group the total efficiency was 83%; acupuncture+estazolam group the total efficiency was 92% acupuncture+compound vitamin B group1.2 PSQI1.2.1 Within group comparisonThe sleep quality, sleep duration, sleep disturbance, and total score of the compound score in the treatment of acupuncture plus VitC PSQI group were significantly improved after 4 weeks (P<0.05).Sham acupuncture+AI our two groups treatment after 4 weeks of PSQI scores in sleep quality, sleep time, total score and treatment before compared were significantly improved (P< 0.05).Acupuncture plus moxa our two groups treatment after 4 weeks of PSQI scores in sleep quality, sleep time, sleep time, sleep efficiency, total score and treatment before compared were significantly improved (P< 0.05).1.2.2 Comparison between groupsAfter 4 weeks of treatment, PSQI score of acupuncture plus estazolam group was significantly lower than sham acupuncture+estazolam group (P<0.05).Treatment after 4 weeks of PSQI Scale total score of acupuncture plus moxa our estazolam group and sham acupuncture+estazolam group were significantly lower than those of the acupuncture+compound vitamin B group (P< 0.05) difference was statistically significant.1.2.3 Difference between groupsTreatment after 4 weeks of PSQI Scale total score difference of acupuncture plus moxa our estazolam group and sham acupuncture+AI our estazolam group were significantly higher than that of acupuncture and compound vitamin B group (P< 0.05); Acupuncture plus moxa our estazolam group than sham acupuncture +estazolam group (P> 0.05) differences had no statistical significance (P> 0.05).After 4 weeks of treatment and treatment of PSQI daytime dysfunction score difference of acupuncture and compound vitamin B group was significantly higher than that of sham acupuncture+AI division of estazolam group (P< 0.05); Acupuncture plus moxa our estazolam group than sham acupuncture+ estazolam group but the difference was not statistically significant (P> 0.05)1.3 psychology parameter1.3.1 Comparison between groupsAfter 4 weeks treatment with scores of SAS and SDS of the sham acupuncture +estazolam group, acupuncture plus moxa our estazolam group was better than acupuncture+compound vitamin B group (P< 0.05) and sham acupuncture+AI our estazolam group and acupuncture plus moxa division of estazolam group compared no significant difference (P> 0.05).1.3.2 Intra group comparisonAfter 4 weeks of treatment, sham acupuncture+estazolam group, acupuncture plus moxa our estazolam group and acupuncture combined with compound vitamin B group, three groups of SDS, SAS score and treatment before compared were significantly improved (P< 0.05).2 Recurrence rate comparison:The markedly effective patients in group 3 at the end of treatment 2 weeks were followed up, sham acupuncture+8 cases of estazolam group recurrence, the recurrence rate was 66.7% and acupuncture+compound VitC group 3 cases of recurrence, the recurrence rate was 34%, acupuncture plus moxa our estazolam group recurrence in 7 cases, the recurrence rate was 58.3%; the markedly effective patients in group 3 at the end of treatment 4 weeks follow-up, sham acupuncture+10 cases of estazolam group recurrence, the recurrence rate was 83%, acupuncture+compound vitamin B group of 4 cases of recurrence, the recurrence rate was 30.7%, acupuncture plus moxa our estazolam group recurrence in 7 cases, the recurrence rate was 58.3%3 Security comparisonDuring treatment sham acupuncture+AI our estazolam group 1 cases of patients after treatment after taking the medicine, gastrointestinal discomfort, mild dizziness, lethargy,2 patients appeared mild dizziness, lethargy, adverse reaction incidence rate of 25%; Acupuncture plus moxa our estazolam group 2 patients appeared mild dizziness, lethargy, adverse reactions occur rate is 17%; examination of blood routine, urine routine, liver function (ALT), renal function (serum creatinine, urea nitrogen). Liver and kidney, blood analysis and other examination showed no abnormalities, no drug related and may be related to serious adverse reactions, the patient’s systemic and local tolerance is good. Acupuncture+compound vitamin B group with fly needle is quick and painless needle, not found in patients with subcutaneous congestion, pain, fear, dizziness, drowsiness, gastrointestinal reaction.4 Correlation analysis of psychological and sleep parametersThere was a positive correlation between PSQI score improvement and SAS improvement, improve the quality of sleep in PSQI and SDS, SAS was positively related to improvement. A significant positive correlation between sleep disorders in PSQI and improved SAS. Positively related to sleep time in PSQI and improved SAS.Conclusion1 Points group in the improvement of PSQI scale and reduce the recurrence rate is better than non acupoint group; PSQI scale in the daytime dysfunction score improvement points group is better than non acupoint group.2 There was significant correlation between PSQI scale and self rating Anxiety Scale (SAS) scale and self rating Depression Scale (SDS) score. There was a significant correlation between the improvement of sleep quality and the degree of anxiety in the two groups, and there was no significant correlation between the improvement of the degree of depression and the degree of depression. |
PDF Full Text Request