The Clinical Research Of "The Pricking Method Of Removing Blood Stasis For Promoting Tissue Regeneration" Combined Xiaoyaosan For Post-stroke Depression

ObjectiveTo evaluate the efficacy and safety of "The Pricking Method of Removing Blood Stasis for Promoting Tissue Regeneration" combined with Xiaoyaosan in the treatment of post-stroke depression. Provide a new way of thinking for TCM treatment of PSD, a clinical study foundation for deepening the research on the mechanism of future.MethodsThe 60 cases of PSD patients which met the inclusion criteria, implementation of single-blind, randomized, controlled trial, were randomly divided into "the pricking method of removing blood stasis for promoting tissue regeneration" group (hereinafter referred to as the pricking group) combined Xiaoyaosan group(RP-X), Xiaoyaosan group(X) and "the pricking method of removing blood stasis for promoting tissue regeneration" group (RP) (hereinafter referred to as the pricking group),20 cases in each group. Each group was given routine cerebrovascular disease drug treatment. The RP-X group were gived pricking Medicament combine the traditional Chinese medicine Xiaoyaosan, while X group only treated by Xiaoyaosan and RP group treated by pricking Medicine. Pricking medicament tank acupoints are DU20, LI4, LR3, SP6, each treatment interval of three days.5 times in 15 days for a course of treatment, a rest for a week after one course and take for 2 courses obsevted after every courses. Traditional Chinese medicine Xiaosan were taken by a daily dose,15 days for a course, a rest for a week after one course and take for 2 courses obsevted after every courses. Taken Comparative observation the changes of HAMD-24, BI and traditional Chinese medicine in stroke symptoms scale scores of the three groups of patients between after every course to evaluate the clinical efficacy of them.Results1. Before and after:In terms of HAMD scale score, All of the groups after the 1st and the 2nd treatment have significantly reduced than before (p＜O.01); In BI score, three groups of total after treatment have significantly increased than before (p＜0.01); In stroke scale score of syndromes, three groups of after total treatment had significantly lower than before (p＜O.01).2.Among groups:There were no difference among three groups before treatments (P>0.05), Contrast grade difference, in terms of HAMD scale score, after the first course of treatment the RP-X group and the X group were superior to RP group (p＜O.05), and there had no difference between the RP-X group and the X group(p＞O.05); After 2 courses, RP group had the largest decline among these three gorups (p＜ 0.05). Compared to BI and stroke disease clinical symptom score difference, closed at the end of the total course of RP-X group were superior to X group and RP group (p＜0.05), X group and RP group was no significant difference in BI and stroke disease clinical symptom score (p＞0.05).3. Efficacy:the efficacy of PSD in three group were 85%in RP-X group, 75%in X group and 40%in RP group, three contrast among them has significant differences (p＜0.05).ConclusionBoth of "The Pricking Method of Removing Blood Stasis for Promoting Tissue Regeneration " and the TCM Xiaoyaosan have significant effects on treatment of post-stroke depression, combined these two treatment can get the best efficacy, and it can also improve the ability of daily life of patients which reduce the symtoms fo stroke in TCM. This method can get steady and strong effect, less adverse reaction, for improving the physical and mental health of patients with PSD is safe and effective, and worthy of popularization and application.