Clinical Study Of Serum Vitamin D And Immune Function In Neonates With Infectious Pneumonia

Objective:Via the research of the erum vitamin D and T lymphocyte subsets and immunoglobulin on neonatal infectious pneumonia, to explore the significance of changes related to erum vitamin D and immunity in infectious pneumonia.Methods:47 newborns were collected in the neonatal ward hospitalized newborns of the Second Affiliated Hospital of Kunming Medical University from January 2015 to February 2016, excluded three of the children who with neonatal disease history or his mother with gestational diabetes mellitus and selected 44 cases of them as earch object.41 newborns jaundice with no obvious infection as the control group. Both study groups accept blood testing of vitamin D levels, T lymphocyte subsets, immunoglobulin, on the day they admitted to hospital, and regular check CRP, PCT, blood, blood culture, etc.Results:1. Clinical data of both two groups of gender, gestational age, birth weight, hospital birth weight, birth way, feeding mode and other factors which may affect the children with vitamin D and immune function of the differences were not statistically significant. Two sets of data are comparable.2. The average level of erum vitamin D in pneumonia group was (16.42+5.95) ng/mL, the control group (15.73+5.62) ng/mL, the difference between the two groups was not statistically significant (P> 0.05), the vitamin D amount of two groups were lower than 20 ng/mL.3. The average level of CD3+ in pneumonia group was (76.15+9.12),and the control group was (82.22+5.23), difference was statistically significant (P< 0.05); pneumonia group was (53.24+10.53), the average level of CD3+CD4+ in the control group was (60.44+657),difference was statistically significant (P< 0.05); pneumonia group and control group IgM average level were 0.22 (0.12-0.29),0.15 (0.12-0.18) the difference between the two groups has statistical significance (P< 0.05); two groups of CD3+CD8+, CD4+/CD,*, IgG have no statistical significance (P> 0.05).4. Correlation analys was of n=85 patients with vitamin D levels and immune function that vitamin D levels are positively related with CD3+(r=0.44 P=0.001).5. The two logistic regression analyses showed that CD3+, CD3+CD4+reduction is a risk factor for pneumonia,and Vitamin D is a protective factor for pneumonia.Conclusion(s)1. The levels of vitamin D were generally low in the neonates with infectious pneumonia group and control group, which were lower than those in 20 ng/mL, and there was no difference in serum vitamin D levels between the two groups.2 The immune function of children with infectious pneumonia was inhibited to different degrees, with the reduction of CD3+CD4+, and CD3+as the main factors.3. IgM may play an important role in humoral immunity in neonates with infectious pneumonia.