The Experience Research On The Hepatitis B Virus-related Cirrhosis Treating By Professor XueBoyu Based On Data Mining

Objective:Through the analysis on the types of syndrome, disease location, disease syndrome symptoms, commonly used drugs, commonly used couplet medicines, commonly used combinations of drugs and other related information of the Professor Xue Boyu’s 264 cases of HBV-related cirrhosis medical records, and then summarize and refine his experience elements in treating HBV-related cirrhosis. This study aims to inherit Professor Xue Boyu’s treating experience and provide some ideas for the treatment of HBV-related cirrhosis.Methods:Collect professor Xue Boyu’s patients’medical records which are diagnosed with HBV-related cirrhosis in the outpatient service and completed.Export these records after using Medcase system for data entry.This study uses Microsoft Office Excel 2013, data Association rules Analysis Platform (ARAP, Association Rule Analysis Platform), Xminer Operation Tool Operation tools for frequency Analysis, mining Association Rule Analysis and clustering Analysis method to deal with the raw data. According to the result of mining to explore professor Xue Boyu’s syndrome discriminating and treating experience of this disease.Results:1) certificate, certificate:the analysis of the frequency:high frequency (> 10%) evidence for liver and kidney Yin deficiency of syndrome (24.62%)> wet trapped pixu (spleen deficient) (23.11%)> liver spleen deficiency (14.39%)> liver blood stasis (14.02%). After been split type, high frequency of disease syndrome factor (> 10%) for liver (99.62%)> spleen (75.76%)> kidney (31.44%). High frequency of disease syndrome factor (> 10%) for qi deficiency (89.39%)> blood stasis (88.64%)> wet (71.21%)> Yin deficiency (68.18%)> hot (45.83%)> and qi (43.94%). Through correlation analysis:correlation between strong evidence combination type mainly has:liver qi stagnation and blood stasis+Spleen deficiency and dampness, syndrome of dampness-heat stagnating in spleen+liver and kidney Yin deficiency syndrome, qi and blood stasis+liver and kidney Yin deficiency syndrome, (syndrome of dampness-heat stagnating in spleen, liver and kidney Yin deficiency syndrome)+qi and blood stasis syndrome, syndrome of dampness-heat stagnating in spleen+(qi and blood stasis, liver and kidney Yin deficiency syndrome), syndrome of dampness-heat of liver channel with exterior syndrome+ spleen and lung qi deficiency syndrome, syndrome of dampness-heat stagnating in spleen+qi and blood stasis. Syndrome factor combination:Qi deficiency+liver,blood stasis+liver, (blood stasis, qi deficiency)+liver, blood stasis+qi deficiency,(blood stasis, liver)+qi deficiency, blood stasis+(qi deficiency, liver), qi deficiency+(blood stasis, liver), qi deficiency, blood stasis.2)The common symptoms of this disease is miscellaneous, distribution of the whole body, frequency analysis:high frequency symptoms according to the frequency in the frequency (> 10%) from high to low were fatigue (31.44%)> dry mouth (20.08%)> loose stool (15.15%)> wakefulness(14.39%)> abdominal distension (14.02%)>fear of cold(13.64%)> bitter taste(12.50%)> gringival hemorrhage (12.12%). The most common tongue nature is red tongue (34.09%) and the moss thin is the most common tongue coating(87.50%).Analysis of the correlation shows five common symptoms combination:wakefulness+fatigue, gringival hemorrhage+fatigue, gringival hemorrhage+dry mouth, loose stool+fatigue, fatigue+dry mouth.3)Treatment:treatment of frequency analysis of high frequency (> 10%) for purificating and eliminating(69.32%)> emolliating the liver(56.06%)> tomifying qi (44.32%)>nourishing yin (20.83%)> tonifying spleen (17.05%)> dissipating blood stasis(12.50%). Through correlation analysis:emolliating the liver+purificating and eliminating,tomifying qi+emolliating the liver,tomifying qi+purificating and eliminating.4) Medication:frequency analysisof in the top 30 of the drugs:drug efficacy:tonic medicine> drugs for regulating Qi flow> drug for invigorating blood circulation and eliminating stasis> heat-clearing drug.Frequency of channel tropism of drug liver> spleen> lung> stomach> kidney= heartFrequency of medicinal properties are warm-natured and mild-natured.Frequency of flavour of drugs:sweetish tastet>bitterness>pungent. Top ten drugsare astragalus membranaceus,salvia miltiorrhiza, fried atractylodes, radix paeoniae rubra, rhizoma polygonati, radix paeoniae alba, radix aucklandiae, August Zagreb, rhizoma zedoariae, charred fructus crataegi. Tonic drugs appeare in all 4627 drugs accounted for 34.25%, among them the Qi tonic drugs accounted for 16.50%, the Yin tonic drugsaccounted for 11.70%.Followed by heat-clearing drugs (13.65%)> drugs for regulating QI flow(11.16%)> drug for invigorating blood circulation and eliminating stasis (11.05%). The remaining 13 kinds of drugs account for< 10%. This study find 12 kinds of channel tropism, a top for liver> stomach> lung>spleen> kidney.This is consistent to the disease syndrome factors which are lung> liver> spleen> kidney> stomach. The total of 19 kinds of properties and flavour of drugs are extracted. Frequency of all medicinal properties are warm-natured>cold-natured>mild-natured>micro cold-natured>micro warm-natured. Frequency of flavour of all drugs:sweetish tastet>pungent>bitterness.Correlation analysis to extract six commonly used couplet medicines on:astragalus membranaceus+solomonseal, fried atractylodes+astragalus membranaceus, astragalus membranaceus+salvia miltiorrhiza,salvia miltiorrhiza+radix paeoniae rubra, radix paeoniae rubra+radix paeoniae alba, astragalus membranaceus+radix paeoniae rubra. Through clustering analysis to extract the four groups of basic prescription, almost all by tonic medicine, drug for invigorating blood circulation and eliminating stasis and heat-clearing drug.Conclusion:Professor Xue Boyu believes the location of HBV-related cirrhosis is more in the liver, spleen, kidney three internal organs. The disease of qi deficiency and blood stasis, yin deficiency, qi stagnation, dampness, heat is more common. Chronic as the disease is,deficiency of vital-qi is widespread. The clinical medication attends to harmonizing stomach and spleen and Yin fluid. Purificating and eliminating,emolliating the liver,tomifying qi,nourishing yin,tonifying spleen,dissipating blood stasis based on syndrome differentiation is common. The more common combinations of drugs are tonifying qi and blood,nourishing Yin of liver and kidney,clearing heat, invigorating blood circulation and eliminating stasis which often with drugs for Qi regulating or tranquilizing by nourishing the heart, the drugs for removing dampness and jaundice through diuresis,reducing phlegm and resolving masses drug and drugs for inducing diuresis to alleviate edema.