| Objective:Exploration of Sanhuang Decoction Combined with postmenopausal breast cancer adjuvant endocrine treatment regulation of breast cancer patients with the body in the state of chronic stress and to exploration of Sanhuang Decoction could increase postmenopausal efficacy of adjuvant endocrine therapy for breast cancer the clinical mechanism.Method:30 cases meet the inclusion criteria in postmenopausal breast cancer patients divided into two groups:treatment group (30 cases), in accordance with the original plan endocrine therapy, to be taking Sanhuang Decoction; control group (30 cases), according to the original plan of endocrine, follow-up observation. Evaluate the efficacy of the two groups of patients were treated for 6 months, compared two groups of patients with traditional Chinese medicine and stress symptoms score, quality of life score improvement and were measured by the changes of laboratory indexes in two groups of patients with serum stress index (IL-6, IL-8, SOD, NO, T-AOC) and hormone levels, the level of blood lipid and safety indicators.Results:At the end of treatment, there were 15 valid cases in treating group which can be calculated, and 15 in control group.The results showed that:1. Stress symptoms:1) stress symptoms in the treatment group after treatment in February, integral significantly decreased compared with the control group, after treatment in June, stress integral to the normal level (p<0.01). The control group increased stress integral. Is single symptoms:patients in the treatment group were single stress symptoms were compared with those before treatment has improved significantly, especially in the muscles and joints, immunodeficiency, attention, mental quality score before treatment significantly reduced (P< 0.01); control group in the muscles and joints, and concentrating stress symptoms rating points compared with those before treatment increased and grow up with the time, the sleep diet, mental quality aspects stress symptoms have increased.2.TCM symptoms:treatment group because of stress symptoms can be alleviated, therefore compared with the control group earlier improvement of symptom of TCM, and after the end of treatment treatment group TCM syndrome score was significantly lower than the control group, with comparable (P< 0.01). Is single symptoms:patients in the treatment group were God fatigue, palpitations, dizziness, night sweating, headache insomnia, weak waist pain, chest tightness, shortness of breath,will not transfer of seven symptoms and treatment has improved significantly (P< 0.01) compared to; in the control group were only Shenpi fatigue, loss of appetite, chest stuffy short,2 to be not moved four points compared with those before treatment decreased, but did not reach statistically significant differences, palpitations, dizziness, sweating, night sweats, waist and knee pain, headache insomnia symptom score before treatment increased.3.Quality of life:after treatment in two groups patients life has improved, the patients in the treatment group were the most life feel satisfaction (P<0.01). In the control group, patients still exist different degree of worry and fear, the quality of life before and after the treatment.4.Stress index:patients in the treatment group after treatment, serum IL-6, IL-8 and NO were significantly lower than those before treatment (p<0.01), while the control group compared with before treatment had no obvious change or increased slightly. SOD, the level of T-AOC was significantly higher than that before treatment, (p<0.01) the control group compared with before treatment, no change or slightly reduced. Sanhuang Decoction can reduce its oxygen free radical generation, enhance the ability of antioxidation of chronic stress intervention, reduce the body tissue damage and is conducive to disease recovery.5. Two groups of patients before and after treatment, FSH and E2 levels did not appear obvious fluctuation, Sanhuang Decoction on postmenopausal hormone levels of patients had no effect (P>0.05). Observed during two groups of patients with blood lipid levels are in normal level and no significant difference, because of the number of cases and the observation time limit to be, failed to clear the Sanhuang Decoction on blood lipid level influence.6. Two groups of patients during treatment, blood routine, ECQ liver and kidney function in the normal range, no adverse events reported during treatment.Conclusions:1) Sanhuang Decoction for postmenopausal patients with chronic stress intervention can reduce adverse reaction of the treatment of AIS, improve TCM symptoms and improve the quality of life of patients and for postmenopausal breast cancer treatment plays an active role. And three of the patients with hormone levels, and liver and kidney function and other safety indicators have no effect.2) Sanhuang Decoction by antitumor and antioxidant effects, reduce its oxygen free radical generation, enhance the ability of antioxidation of chronic stress intervention, reduce tissue injury, reduce disease progression may, become Chinese medicine for the treatment of AIS Deputy mechanism to provide a new train of thought. |
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