| ObjectiveAromatase inhibitor as the first-line medication of postmenopausal breast cancer patients with endocrine therapy,its efficacy is exact and well tolerated,widely used in the treatment of breast cancer.However,the side effects of long-term use of aromatase inhibitors cannot be igno-red,especially Aromatase inhibitor-associated musculoskeletal symptoms which affecting the daily life and work seriously.It become the main reason of the replacement of therapeutic drugs or even stop for drug tre-atment.Clinically,the treatment of aromatase inhibitor-associated muscul-oskeletal symptoms has no unified standard,mainly through calcium,analg-esic,glucocorticoid and Chinese medicine treatment to relieve symptoms,the treatment efficacy varies.Chinese medicine in the prevention and treatment of western medicine side effects have a unique advantage,Bushen Qiang capsule may be able to alleviate AIMSS.In this study,randomized controled trials were conducted to assess the clinical efficacy of Bushen Qiang jin Capsule in the treatment of aromatase inhibitors related musculoskeletal symptoms by analyzing the relevant indexes before and after treatment in two differet treatment methods.Exploring effective treatment of aromatase inhibitor-associated musculos-keletal symptoms.MethodsA total of 73 patients with breast cancer who underwent the third generation of AI for endocrine therapy were enrolled in the Department of Breast Surgery,from The Second Traditional Chinese Medicine Hospital of Guangdong Province.The subjects were randomly divided into control group and test group.The control group was treated with calcium D3(1#,qd),a total of 6 month.The test group was treated with calcium D3(1#,qd)and Bushen Qiangjin capsule(2#,tid),a total of 6 month.Before treatment,BPI?SF-36?BMD and the safety indexes such as blood routine,liver and kidney function and E2 were measured.After treatment for 3 month,BPI?SF-36 and the safety indexes such as blood routine,liver and kidney function and E2 were measured.BPI?SF-36?BMD and the safety indexes was measured after treatment for 6 month.Use the SPSS21.0 statistical software for build the database and statistical analysis in this study.The measurement data are expressed as mean ± standard deviation.Data analysis is mainly used t test,if not satisfied with normal distrubition or homogeneity of variance,then Wilcoxon rank sum test.If more than two sample comparison,variance analysis will be used.Chi square test suitable for the percentage of data.Association analysis using pearson correlation analysis.ResultsThe results of this study showed that:compared with the control group,the experimental group of the most severe pain,the slightest pain,mean pain,pain at the moment before and after the treatment of the overall mean has a significant decline.In the control group,compared with before treatment,the most severe pain,the slightest pain,the average pain,pain at the moment of overall mean of pain has significant-ly different.Treatment after 6 months compared with before treatment,the most severe pain,the slightest pain,mean pain,pain at the moment of overall mean of pain has significant differences.In the experimental group,compared with before treatment,the most severe pain,the slightest pain,the average pain,pain at the moment of overall mean of pain has significantly different.Treatment after 6 months compared with before treatment,the most severe pain,the slightest pain,mean pain,pain at the moment of overall mean of pain has significantly differences.Compared with the control group,the physiological function(PF),physiological function(RP),body pain(BP),general health status(GH),energy(VT),social function(SF),emotional function(RE),Mental health(MH)in the treatment before and after the overall average has a significant increase.In the control group,after 3 month treatment later,the mean values of PF,RP,BP,GH,SF and MH were significantly different from those before treatment.VT?RE were no significantly different.After 6 month treatment later,there were significant differences in the mean values of PF,RP,BP,GH,SF,RE compared with those before treatment.VT and MH were no significantly different.In the experimental group,after 3 month treatment later,the mean values of PF,RP,BP,GH,VT,SF,RE and MH were significantly different from those before treatment.After 6 mon-th treatment later,there were significant differences in the mean values of PF,RP,BP,GH,VT,SF,RE and MH compared with those before treatment-There was no significant difference in bone mineral density in the exper-imental group before and after treatment even though it rised.And the control group has no significant difference in bone mineral density.Before and after treatment,the safety indicators were no abnormalities,Estrogen levels of patients still in postmenopausal levels.ConclusionThe effect of Bushen Qiangjin capsule on breast cancer AIMSS is mainly manifested in the pain score and quality of life score,bone density has no significant rise,and has no decline.Bushen Qiangjin caps-ule in improving the patient's pain symptoms and improve the quality of ?life of patients has a significant effect,and no significant side effec-ts,estrogen remained at a safe level,does not affect the overall treat-ment of breast cancer.Bushen Qiangjin capsule can effectively treat bre-ast cancer AIMSS,convenient and feasible,it is worth further applicati-on in clinical practice. |
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