Clinical Research Of Decoction For Dissipating Dampness And Descending Turbidity In Patients With Chronic Heart Failure And Hyperuricemia

Objectives To investigate the effect of decoction for dissipating dampness and descendin g turbidity in patients with chronic heart failure(CHF) and hyperuricemia(HUA).Methods 40 patients with CHF and HUA were enrolled and randomly from Third Affili ated Hospital of Nanjing University of TCM of Cardiology,and they were assigned to rec eive the decoction(lremedy/d) or benzbromarone(50mg/d) in addition to their standarad m edications for the treatment of CHF. Serum uric acid (UA),the TCM symptom score,seru m homocysteine (Hcy),serum high-sensitivity-C-reactive protein (hs-CRP),safety indicators and adverse reactions are measured during before and after treatment.Results 1.UA level and total effective rate of HUA:a significant reduction in the serum UA level was observed in both groups after 2 weeks,the difference was statistically sign ificant (p<0.01),and there was no statistically significant difference in both groups after t reatment (p>0.05).The total effective rate of HUA between the two groups were no signif icant differences after treatment(p>0.05).3.After 2 weeks, blood Hcy and hs-CRP levels i n the treatment group was decreased significantly (p<0.01)than before treatment, and the decoction also demonstrated better performance in comparison to the control group with r espect to blood Hcy levels,the difference between the two groups was statistically signific ant (p<0.05).After treatment,comparison between the two groups of blood hs-CRP levels, the difference was not statistically significant (p>0.05).4.TCM syndrome scores and total effective rate:After 2 weeks, the treatment group demonstrated a significantly greater redu ction than both group, the difference was statistically significant (p both<0.01); while the TCM syndrome scores in the control group was seldom declined than before treatment, the difference was not statistically significant (p>0.05).after treatment, the total effective r ate was 70% In the treatment group,while the control group was 15%.The total effective rate between the two groups of patients was statistically significant difference(p<0.05).5. Adverse reactions:Two cases of the control group patients noisy epigastric discomfort, sto ol frequency increased, one case of skin itching, facial redness, two cases of gout, one c ase of elevated INR levels, the overall incidence rate was 40%, the total adverse reactio ns between the two groups incidence, the difference was statistically significant (P<0.05).