Correlation Between Plasma ET-1 And Insulin Resistance In Patients With Impaired Glucose Regulation With Nonalcoholic Fatty Liver Disease

ObjectiveTo investigate the correlation between plasma endothelin-1 and insulin resistance in patients of impaired glucose regulation (IGR)with nonalcoholic fatty liver disease(NAFLD).Materials and MethodsTotally 92 impaired glucose regulation patients were divided into two groups including 58 diabetes without NAFLD(group A), and 34 diabeteswith NAFLD (group B). The level of height, weight, systolic pressure(SBP), diastolic pressure(DBP), plasma endothelin-1(ET-1), fasting plasma glucose(FPG), fasting insulin(FINS), hemoglobin Alc(HbAlc),total cholesterol(TC), triglyceride(TG), high density lipoprotein(HDL-C), low density lipoprotein(LDL-C), alanine aminotransferase(ALT) aspartic aminotransferase(AST)and glutamyl transpeptidase(GGT)were measured. Body mass index(BMI), index of insulin resistance(HOMA-IR), insulin action index(IAI)and quantitative insulin sensitivity check index(QUICKI)were calculated.ResultsThe level of weight、BMI、FINS、HOMA-IR、ET-1、SBP、DBP、ALT、AST、 TG、HDL-C in group B were significantly higher than those in group A(P<0.05). And the level of IAI、QUICKI in group B was significantly lower than those in group A(P<0.05).The Pearson correlation analysis showed that the level of ET-1 was positive correlated with weight、BMI、FINS、 HOMA-IR(P<0.01) and was negative correlated with IAI、QUICKI(P<0.01).ConclusionThe IGR with NAFLD patients show an increased ET-1 level and more severity of insulin resistance. So, these patients needs early endothelial dysfunction and insulin resistance intervention to prevent the atherosclerosis.