The Clinic Analysis Of Insulin Risistance,Glucose And Lipid Metabolism In Patients With Nonalcoholic Fatty Liver Disease

Objective To analyse the insulin risistance(IR),glucose and lipid metabolism in patients with nonalcoholic fatty liver disease(NAFLD) Methods Body mass index(BMI),waist circumference(WC),waist -to–hip rate(WHR),blood press,liver fuction,triglycerin(TG),low-density lipoprotein(LDL),high- density lipoprotein(HDL),fasting plasma glucose and insulin(FPG,FINS),postprandial plasma glucose and insulin(2hPG,2hINS)were determined in 137 fatty liver patients(diagnosed by B ultrasonic echograph)and 50 normal control subjects. Homeostasis model assessment insulin resistance index(HOMA-IR) was applied to status of insulin resistance. Results (1) The BMI,WC,WHR,TG,LDL,FINS in the fatty liver patients were significantly higher than those in the controls, HDL were lower, P<0.01 for all.(2) HOMA-IR in the fatty liver patients were relevant to the degree of the fatty liver(diagnosed by B ultrasonic echograph),P<0.01。(3) The FINS,2hINS,HOMA-IR in the fatty liver patients were significantly higher than those in the controls,P<0.001。(4)Among the fatty liver,the FPG,FINS,2hPG,2 hINS,HOMA-IR in the non-obesity were same as those in obesity,P>0.05。Conclusion (1)Hyperinsulinemia,abnormal glucose and lipide metabolism were significant in the patients with NAFLD。(2)HOMA-IR in the nonalcoholic fatty liver patients were relevant to the degree of the fatty liver(diagnosed by B ultrasonic echograph),with the increase in HOMA-IR, the overall prevalence of severity fatty liver increased gradually。(3)The hyperinsulinemia and IR in the non-obesity nonalcoholic fatty liver patients were same as those in the obesity nonalcoholic fatty liver patients。...