Effect Of Sini-Decoction On Thyroid Function In Critical Patients With Kidney-yang Deficiency Syndrome

Objective:To observe the effect of Si-ni Decoction on Thyroid hormone in Critical patients with Kindey-yang Deficiency Syndrome, and to explore its possible mechanisms, estimate whether the result could provide new ideas and reference to traditional Chinese medicine.Methods:In this prospectie, randomized, single-blinded, controlled study, for ty-six patients who are in my courtyyard ICU and CCU with critical diseas e between MARCH 2015 and March 2016 according to 1:1 proportion are divid ed into control group and treatment group. All of the patients included i n the study on hemodynamic stability, internal environment tend to be ste ady, enteral nutrition contraindications, early nasogastric enteral nutri tion (24-48 hours), the treatment group to pour into Si-ni Decociton 50 m 1 twice, the treatment coursese 7 days. Collect the patient’s four diagno stic data respectively, and record the patient to enteral nutrition and o n the seventh day. Observing the two groups, measure the thyroid hormone (T SH, FT3, FT4, TT3, TT4)and albumin in the circumference venous blood, acu te physiology and chronic health Ⅱ (APACHE Ⅱ) score in the day before n utritional support and the seventh day of enteral nutrition. Data are exp ressed as mean±semor median (with inter quartile range). Differences betw een groups were evaluated using Student’s t-tests, the numerical variable data rank sum test he relations between categorical variables and groups were investigated using the suitable Chi-square test. The correlation be tween continuous variables was evaluated by Spearman’s or Pearson’s cor relation analysis where applicable. he level of statistical signiicance w as set at= 0.05 and PASW SPSS 20.0 for Windows was used for all statist ical computations.Results:Treatment group 23 cases, control group 23cases. Research before the treatment group and control group of sex ratio, age, APACHE Ⅱ target have non-statistics significances. The treatment group and control group before treatment by measured TT3, TT4, FT3, FT4, TSH and propagated change has no obvious difference.7 Days after treatment, TT3, TT4, FT3 and FT4 of the study team and the treatment group have significantly promotion, the treatment group was higher than the control group(P<0.05). Western medicine treatment group curative effect is better than that of control group, and the gastrointestinal complications of enteral nutrition intolerance is less than the control group.Conclusion:(1) Si-ni decoction can effectively improve the thyroid function in patients with kidney Yang deficiency, especially with better effect of patients with heart failure;(2)Hypoalbuminemia is closely linked with NTIS in the occurrence and development;(3) The dynamic change of thyroid hormone can as one of the risk factors of patients and prognosis analysis, combined with other prognostic factors, in particular, can increase the risk of the patient condition judgment.