Effect Of Early Application Of Xuebijing On The Prognosis And Level Of Hs-CRP Of Elderly Patients After Operation

ObjectiveThe aim of this study was to observe the early application of traditional Chinese medicine preparation with heat clearing and removing blood stasis called "Xuebijing" in postoperative prognosis of elderly patients, through the monitoring of the patient’s serum ultra sensitive C reactive protein level to evaluate its efficacy, the comparison of acute physiology and chronic health score, supplemented by calculating hospitalization on different days to evaluate the prognosis of postoperative elderly patients, and to explore the application prospect of clearing away heat and promoting blood circulation treatment in the intensive care unitMethodsThe research includes 50 cases which are accumulated with heat and toxic, blood stasis according to the TCM differentiation as the research objects, and they are randomly divided into two groups--the experimental group and the contrast group both of which are monitored with hs-CRP and APACHE-II, and the length of stay in the intensive care unit was recorded as well. Both of the two groups received the conventional western medicine treatment (including early fluid resuscitation, mechanical ventilation assisted ventilation, infection control, active drug pressure, control of blood glucose, electrolyte acid-base balance and other symptomatic treatment). In addition to the conventional western medicine treatment, the treatment of experimental group was combined with the Xuebijing injection (100ml bid). After that, the author observed the changes of hs-CRP and APACHE-II of the two groups of patients at the same time before and after using the drugs (starting point of time is defined as the initial use of the medication), and the observation lasted for 5 days. At last, we record the length of stay in the intensive care unit after the treatment. And then we collected data and analysed them by statistics.Results1. Through the contrast of the baseline information of two groups (including gender, age, APACHE II, hs-CRP and the time from operation completed to sent to ICU), the difference has no statistical significance (P>0.05), it means that two groups of data are comparable.2. The contrast in the groups before the treatment shows that APACHE II and hs-CRP of both groups of patients have dropped to a certain extent, and the difference has statistical significance (P<0.01). The contrast in the groups after the treatment shows that APACHE II> hs-CRP and the length of stay in ICU after the treatment of both groups of patients have dropped to a certain extent, and the difference has statistical significance (P<0.01)3. The contrast between two groups after the treatment shows that APACHE II, hs-CRP and the length of stay in ICU after the treatment of the experimental group are all lower than those of the contrast group, and the difference has statistical significance (P<0.05).4. On the 5th day, (when the observation period ended), the conditions of patients from the experimental group were better than that of the contrast group, the difference has statistical significance (P<0.05)5. Before the treatment, all the APACHE-Ⅱ、hs-CRP and the length of stay in ICU after the treatment has significant correlation (r=0.693, P<0.01). After 3th day treatment, the APACHE-II and hs-CRP in the test group has significant correlations (0.75<r<1, P<0.01), so was the 5th day.For the contrast group, the APACHE-II> hs-CRP after the treatment has significant correlations (0.50<r<1, P<0.01). When the observation period ended, all the APACHE-Ⅱ、 hs-CRP and the length of stay in ICU have significant correlation (0.40<r<1, P<0.01). Conclusions1. Both conventional western medicine treatment and conventional western medicine treatment combined with Xuebijing injection can improve the condition of postoperative elderly patients.2. Compared to the conventional western medicine treatment, combined with Xuebijing injection could improve the conditions of postoperative elderly patients better.3. In the selection of index to evaluate treatment effect, there is positive correlation between APACHE-Ⅱ、hs-CRP and the length of stay in ICU, which is worth clinical promoting.