Clinical Epidemiological Studies On Nconventional Changes Of Liver Enzymeactivity In Patients With Chronic Hepatitis B

Objective:To investigate factors associated with the unconventional changes of liver enzyme activity in chronic hepatitis B patients, and improved the accuracy of judging the degree of liver damage. Methods: The clinical information of 519 chronic hepatitis B patients during September 2010 and September 2015 were collected. The patients were divided respectively into two groups: Taking serum liver enzyme activity values more than the normal range as control group, taking serum liver enzyme activity values in the normal range as experimental group. Taking serum liver enzyme activity values whether or not more than the normal range as dependent variables and age, gender, with cirrhosis or not, systolic pressure(SBP), diastolic pressure(DBP), body mass index(BMI), liver and kidney function indicators as independent variable, and then data are analyzed by multivariate logistic regression analysis. Result: The unconventional change rate of serum ALT activity in male patients is lowest(P<0.05). Multivariate unconditional logistic regression analysis showed that, combined liver cirrhosis and the serum UA, ALB, GLOB,TBA, DBIL, Cr, BUN, K+, Na+, Cl- and Ca2+ values related to the unconventional changes of liver enzyme activity. Conclusion: Combined liver cirrhosis, serum ALB, GLOB, DBIL, TBA, UA, BUN, Cr, K+, Na+, Cl- and Ca2+ may be important factors influencing on the unconventional changes of serum liver enzyme activity. When we are evaluating the liver damage in chronic hepatitis B patients depending on the upper limit of liver enzyme activity,this factors can not be ignored, especially combined liver cirrhosis and the change of serum UA、 Cr、 BUN、Cland Ca2+ levels may be interfered the changes of serum liver activity.