The Value Ofserum Hcy,CysCand UA For End-organ Damage Assessment In H-hypertensive

Objective: Toanalyze the value of serum Homocyseitne(Hcy),CystatinC(CysC) and serum uric acid(UA) foratherosclerosis(AS) and renal damage assessmentin essential H- hypertensionpatients.Methods: The study was performed on 132 H- hypertension patients. Carotidintima-mediathickness(cIMT) was measured by Doppler ultrasonography;according to the result of carotid artery atherosclerosis all patients were devided three groups. Using enzyme-linked immunosorbent method(enzyme- linked immunosorbent assay, ELISA) were measured serum Hcy, CysC and UA level, at the same time detection related biochemical indicators. Respectively on the basis of cIMT and glomerular filtration rate,GFR)) subjects to the group, explore serum Hcy, CysC, UA level and cIMT and GFR statistical relationship.Results: 1.In the process of investigating the connectionbetween serum Hcy, CysC, UA and cIMT, Based on the level of cIMT, all the subjects were divided into normal cIMT group, thickened cIMT group and mottling formation group.We found that:(1) Based on the level of cIMT,all subjects were divided into normal cIMT group, thickened cIMT group and mottling formation group.There was no significantly difference in blood glucose,blood lipid,serum creatinine and blood urea nitrogen creatinine,total cholesterol,triglyceride,low density lippprotein cholesterol levels(p>0.05),but the difference in the Hcy,Cyst-C and UA were statistically significant(p<0.05) among the three groups;(2)The cIMT level was positively correlated with Hcy, Cyst-C and UA levels(r=0.26,0.30,0.23, P<0.05).When cIMT level was taken as the dependent variable,unconditioned Logistic regression analysis showed that Hcy,Cyst-C and UA and HDL were independent risk factors for cIMT(OR=1.215,4.788,1.008,P<0.05).At the last part of our research, according to the glomerular filtration rate(GFR) divided the patients into normal renal function groups(GFR ?90 ml/min), renal function injury group(60 ~ 90 ml/min GRF), mild and moderate damage of renal function group((GFR ? ?60 ml/min). According to the level of blood pressure can be divided into high blood pressure level 1((140~159/90~99mmHg)), high blood pressure level 2(160~179/100~109mmHg), high blood pressure level 3(?180/110mmHg), line test and compare the three groups of serum Hcy, Cyst- C, UA, blood glucose, blood lipid, urea nitrogen, creatinine(Scr), and other levels, analyze its relationship with GFR, Hcy multivariate linear regression analysis. we got some findings as following:(1) Renal function more than mild and moderate groups of Hcy, Cyst-C, UA levels higher than mild renal function injury group and normal renal function, renal function injury group is higher than the normal renal function group(all P < 0.05). Hypertension level 3 group serum Hcy, Cyst- C, higher UA than high blood pressure level 1 and level 2 group, hypertension group 2 levels of serum Hcy, Cyst-C, UAabove grade 1 hypertension group(all P ? 0.05). Between three groups of blood glucose, blood lipid, urea nitrogen, uric acid(UA) there was no statistically significant difference level.(2) GFR and Hcy, Cyst-C, UA, SBP, DBP, UACR showed a negative correlation(r=-0.316,-0.319,-0.242,-0.201,-0.282,-0.241;P<0.05).Conclusion: Serum Hcy,CysC and UA levels are closely associated with blood pressure, cIMT and GFR in H- hypertension patients. They were independent risk factors for cIMT and GFR.They may participate in the development of H- hypertension and affect the process of AS and renal injury.Combined detection of serum Hcy,CysC and UA provide a new serological basis to evaluate the severity of cardiovascular and renal complications for H- hypertension patients. They have potential clinical value.