| ObjectivesComparing gout damp and hot accumulate knot the symptoms and signs before and after the treatment, pain relief time and laboratory indexes (blood uric acid, blood sedimentatio,C-reactive,protein) to improve the situation.The Huhuang Turbid ity-purgating and Chubi prescriptionin addition to making evaluation of the safety and effectiveness of it,also provide clinical basis for further clinical application, relieve patients’pain, patients to reduce the economic burden.MethodsUsing randomized controlled study method, according to the inclusion criteria, 66 patients were collected.Then I divided the patients into experimental group and the control group,each group has 33 patients.Two groups in the process of test due to poor patient compliance each fall off in 1 case, at last, total number of cases was 64 cases, experimental group and the control group (n= 32). The treatment of the control group was the diclofenac sodium delayed treatment; and the reatment group given diclofenac sodium zyban add Huhuang Turbidity-purgating and Chubi prescriptionin addition to the bi particles the Chinese medicine treatment; Two groups strictly, low purine food, drinking enough water, avoid overworked, cold,7 days of treatment with comprehensive analysis and comparison of the observation indexes of statistical software, the final evaluation of clinical effect.Results1 Comparison of the baseline of the two groupsI divided the patients into two groups, the treatment group has 32 cases,30 male and 2 female, with an average age of 47.56±13.75 years old age, average duration of 343.44±597.7 days; Signs and symptoms score of 21.93±4.49 points; The control group owed 32 cases (31 male and 1 female, the average age was 46.28±12.97 years, average duration of 362.97±513.2 days; Signs and symptoms score of 21.28±4.18points; Appeal the indicators, each index signs and symptoms and laboratory indicators (UA, CRP and ESR) were no statistical difference (p> 0.05), and indicated that the two groups was comparable.2 Comparison of the clinical efficacy of treatment in the two groupsThe effective rate of the Treatment group was 93.75%, among them,15 cases clinical control,11 cases had great effect,4 cases were effective, invalid 2 cases; Control effective rate was 78.13%, of which 8 cases reached clinical control,10 cases had great effect,7cases were effective,7 casess invalid.The difference was statistically remarkable (P< 0.05).3 Comparison of laboratory parameters after the treatment.Within the group curative effect comparison:the results showed that after treatment the indicators in the experimental group and the control way comparative differences are statistically significant (P< 0.05); Instructions in the two groups after treatment of joint pain, joint swelling, tenderness and restricted activity, fever, thirst, upset and urinate short yellow and laboratory indexes (UA, ESR and CRP) were improved.Signs and symptoms curative effect comparison between groups:(1) syndrome before and after treatment curative effect between the difference groups, results show that the two groups in improving the patients’pain, fever, thirst, upset, urinate short yellow and total scores, the difference was statistically significant (P< 0.05), the test group curative effect is superior to control group in improving the appeal; Two groups in tenderness, swelling, restricted movement no statistically significant differences (P>0.05), not prove group in improving patients with tenderness, swelling, restricted movement curative effect is superior to the control group. (2) is compared between two groups were pain relief time difference was statistically significant (P< 0.05), the test group compared with control group, pain relief more quickly. (3) laboratory index difference between groups before and after the treatment, the result shows that improving blood sedimentation difference between two groups had no statistical significance (P> 0.05); In the improvement of C-reactive protein, the difference of blood uric acid was statistically significant (P< 0.05), in patients with lower C reactive protein, blood uric acid, experimental group than control effect is better, but in terms of reducing blood sedimentation, cannot prove that experimental group is better than the control group.4 Comparison of safety after four treatment groupsTwo groups of patients’blood test, liver and kidney function were negative after treatment; Control group occurred 1 case of gastrointestinal discomfort,but I didn’t gave treatment because he was self-healing after 3hours.ConclusionsHuhuang Turbidity-purgating and Chubi prescriptionin addition to the joint zyban diclofenac sodium bi particles and the simple use of diclofenac sodium zyban treat gout damp and hot accumulate knot in joint pain, joint-swellen, tenderness and restricted activity, fever, thirst, upset, urine yellow wait for symptoms and signs and laboratory indexes (UA, ESR and CRP) have improved, but the Huhuang Turbidity-purgating and Chubi prescriptionin addition to the joint of diclofenac sodium bi particles zyban treat gout damp and hot accumulate knot the overall efficacy of diclofenac sodium zyban alone is better, the total effective rate is higher, therefore, Huhuang Turbidity-purgating and Chubi prescriptionin addition to the joint of diclofenac sodium bi particles zyban treat gout damp and hot accumulate knot has better clinical curative effect, so, it worth further clinical application, we also need to pay attention to the bad reactions of diclofenacin in the process of the treatment. |
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